...Ffion R. Hammond; Amy Lewis; Zoë C. Speirs; Holly E. Anderson; Tamara Sipka; Lewis G. Williams; Mai Nguyen-Chi; Annemarie H. Meijer; Geert F. Wiegertjes; Philip M. Elks ABSTRACT Innate immune responses to inflammation and infection are complex and represent major challenges for developing much...

...Rujuta Deshpande; Byoungchun Lee; Yuemeng Qiao; Savraj S. Grewal ABSTRACT When infected by enteric pathogenic bacteria, animals need to initiate local and whole-body defence strategies. Although most attention has focused on the role of innate immune anti-bacterial responses, less is known about...

...-microbial peptides (AMPs) through the activation of canonical signaling pathways, and these IFM-synthesized AMPs are essential for survival upon infection. The trunk muscles of zebrafish, a vertebrate model system, also possess the capacity to mount an immune response against bacterial infections, thus...

...Mark R. Cronan; Allison F. Rosenberg; Stefan H. Oehlers; Joseph W. Saelens; Dana M. Sisk; Kristen L. Jurcic Smith; Sunhee Lee; David M. Tobin ABSTRACT Visualization of infection and the associated host response has been challenging in adult vertebrates. Owing to their transparency, zebrafish larvae...

... UCD, revealed that intercurrent infection was the most common precipitant of acute HA and was associated with markers of increased morbidity when compared with other precipitants. To further understand these clinical observations, we developed a model system of metabolic decompensation with HA...