... into the circulation of patients with severe sepsis and the levels of CFH are independently associated with mortality. CFH treatment increased cytotoxicity in the human tubular epithelial cell line HK-2. To better model the intact kidney, we cultured human kidney organoids derived from induced pluripotent stem cells...

.... , Abyzov , A. and Vaccarino , F. M. ( 2017 ). Human induced pluripotent stem cells for modelling neurodevelopmental disorders . Nat. Rev. Neurol. 13 , 265 - 278 . 10.1038/nrneurol.2017.45 Atladóttir , H. Ó. , Thorsen , P. , Østergaard , L. , Schendel , D. E...

... ventral midbrain patterned astrocytes. Human astrocytes Ventral midbrain Induced pluripotent stem cells Disease modeling Parkinson's disease Calcium imaging data analysis Human stem cell-based models Stichting ParkinsonFonds http://dx.doi.org/10.13039/501100008383 110875 110825...

... that is caused by mutations in CLN3 , with most affected individuals carrying at least one allele with a 966 bp deletion. Using CRISPR/Cas9, we corrected the 966 bp deletion mutation in human induced pluripotent stem cells (iPSCs) of a compound heterozygous patient ( CLN3 Δ 966 bp and E295K). We differentiated...

... recovery in patient- compared to control-fibroblasts. As SCAR16 primarily affects the central nervous system we next investigated the HSR in cortical neurons (CNs) derived from induced pluripotent stem cells of SCAR16 patients. We found CNs of patients and controls to be surprisingly resistant to heat...

... sclerosis Induced pluripotent stem cells Tissue engineering Microfluidic devices University of Southern California Viterbi School of Engineering Women in Science and Engineering, University of Southern California 10.13039/100009251 Rose Hills Foundation 10.13039...

..., N-TAF1, which showed decreased expression in post-mortem XDP brain compared with control tissue. Here, we generated XDP patient and control fibroblasts and induced pluripotent stem cells (iPSCs) in order to further probe cellular defects associated with this disease. As initial validation...

... type 1 patient-specific induced pluripotent stem cells (iPSCs) and differentiating these cells into spinal motor neurons. The initial specification of spinal motor neurons was not affected, but these SMA spinal motor neurons specifically degenerated following long-term culture. Moreover, at an early...

... for individuals with late-stage DMD. Results Cardiomyocytes (CMs) were derived from DMD patient-specific induced pluripotent stem cells (iPSCs) and control iPSCs. DMD iPSC-CMs exhibited dystrophin deficiency, as well as increased levels of cytosolic Ca 2+ , mitochondria damage, caspase-3 (CASP3) activation...