... over 200 genomic loci associated with inflammatory bowel disease (IBD). High-effect risk alleles define key roles for genes involved in bacterial response and innate defense. More high-throughput in vivo systems are required to rapidly evaluate therapeutic agents. We visualize, in zebrafish...

...Ross Dobie; Vicky E. MacRae; Chloe Pass; Elspeth M. Milne; S. Faisal Ahmed; Colin Farquharson ABSTRACT Individuals with inflammatory bowel disease (IBD) often present with poor bone health. The development of targeted therapies for this bone loss requires a fuller understanding of the underlying...

... ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Adherent-invasive E. coli Dysbiosis IBD CRC Colibactin Inflammatory bowel disease (IBD) is a group of inflammatory disorders of the intestine. The most...

... proliferation of intestinal epithelial cells (IECs), with pathologies reminiscent of inflammatory bowel disease (IBD), including apoptosis of goblet cells, abnormal mucosecretion, bacterial overgrowth and leukocyte infiltration. The mutant IECs exhibit vacuolation, microvillus atrophy and impaired proliferation...