...Jenny A. F. Vermeer; Jonathan Ient; Bostjan Markelc; Jakob Kaeppler; Lydie M. O. Barbeau; Arjan J. Groot; Ruth J. Muschel; Marc A. Vooijs ABSTRACT Intratumoural hypoxia is a common characteristic of malignant treatment-resistant cancers. However, hypoxia-modification strategies for the clinic...

... in murine models. Glycolysis Lactate dehydrogenase A FX11 Mycobacterium tuberculosis Granuloma Hypoxia Immunometabolism Host-directed therapy Tuberculosis (TB) is the leading cause of mortality from a single infectious agent globally ( WHO, 2018 ) and its treatment includes 6-month...

... that insufficient arginine/nitric oxide synthesis limits blood flow in the intestinal microvasculature, leading to hypoxia, mucosal damage and NEC in the premature intestine after formula feeding. Formula feeding led to increased intestinal hypoxia in pups at postnatal day (P)1 and P5, but not in more mature pups...

..., distribution and reproduction in any medium provided that the original work is properly attributed. Summary: This Review details the potential of photoacoustic imaging to visualise features of the tumour microenvironment such as blood vessels, hypoxia, fibrosis and immune infiltrate to provide...

...Joshua L. Bonkowsky; Jong-Hyun Son ABSTRACT The developing nervous system depends upon precise regulation of oxygen levels. Hypoxia, the condition of low oxygen concentration, can interrupt developmental sequences and cause a range of molecular, cellular and neuronal changes and injuries. The roles...

...Philip M. Elks; Stephen A. Renshaw; Annemarie H. Meijer; Sarah R. Walmsley; Fredericus J. van Eeden ABSTRACT A low level of tissue oxygen (hypoxia) is a physiological feature of a wide range of diseases, from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive hydroxylase enzymes...

...Daniel Bandarra; John Biddlestone; Sharon Mudie; H.-Arno J. Müller; Sonia Rocha Hypoxia and inflammation are intimately linked. It is known that nuclear factor κB (NF-κB) regulates the hypoxia-inducible factor (HIF) system, but little is known about how HIF regulates NF-κB. Here, we show that HIF...

.... Therefore, we hypothesized that in vitro liver-stage malaria infection efficiencies might improve under hypoxia. Using the infection of micropatterned co-cultures with Plasmodium berghei , Plasmodium yoelii or Plasmodium falciparum as a model, we observed that ambient hypoxia resulted in increased survival...