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1-3 of 3
Keywords: Hypothalamus
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Journal Articles
Journal:
Disease Models & Mechanisms
Dis Model Mech (2017) 10 (6): 679–689.
Published: 1 June 2017
... nucleus of the hypothalamus, sense the nutrient status of the organism and integrate signals from peripheral hormones including pancreas-derived insulin and adipocyte-derived leptin to regulate calorie intake, glucose metabolism and energy expenditure. The arcuate neurons are tightly connected to other...
Includes: Supplementary data
Journal Articles
In collection:
Metabolic Disorders
Eva Baquedano, Emma Burgos-Ramos, Sandra Canelles, Agueda González-Rodríguez, Julie A. Chowen, Jesús Argente, Vicente Barrios, Angela M. Valverde, Laura M. Frago
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (5): 573–583.
Published: 1 May 2016
... because IRS proteins mediate the pleiotropic effects of insulin-like growth factor-I (IGF-I) and insulin on metabolism, mitogenesis and cell survival. The hypothalamus might play a key role in the early onset of diabetes, owing to its involvement in the control of glucose homeostasis and energy balance...
Journal Articles
In collection:
Metabolic Disorders
Malgorzata S. Martin-Gronert, Claire J. Stocker, Edward T. Wargent, Roselle L. Cripps, Alastair S. Garfield, Zorica Jovanovic, Giuseppe D'Agostino, Giles S. H. Yeo, Michael A. Cawthorne, Jonathan R. S. Arch, Lora K. Heisler, Susan E. Ozanne
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (4): 401–412.
Published: 1 April 2016
... of 5-HT 2C R, the primary 5-HT receptor influencing appetite, in the fetal, neonatal and adult hypothalamus. As expected, a reduction of 5-HT 2C R was associated with impaired sensitivity to 5-HT-mediated appetite suppression in adulthood. 5-HT primarily achieves effects on appetite by 5-HT 2C R...