... and neurological impairments. The authors show that an NO donor ameliorates the glucose-exposure-induced dysfunction in the tectal neurovascular unit and whole-organism behaviour. Nitric oxide NO donor Hyperglycemia Diabetes Neurovascular coupling National Centre for Replacement, Refinement...

...Yanyi Sun; Qiuyun Wang; Yuehua Fang; Chunfang Wu; Guoping Lu; Zhenyue Chen ABSTRACT Hyperglycemia is an independent risk factor for diabetic cardiomyopathy in humans; however, the underlying mechanisms have not been thoroughly elucidated. Zebrafish ( Danio rerio ) was used in this study as a novel...

... developed to study the underlying mechanisms of GDM-induced fetal eye malformation. In this study, a high concentration of glucose (0.2 mmol per egg) was injected into the air sac of chick embryos on embryo development day (EDD) 1 to develop a hyperglycemia model. Results showed that 47.3% of embryonic eye...

... understood. Although it is often assumed that hyperglycemia causes mitochondrial oxidative stress in diabetes, a recent study reported lower mitochondrial superoxide and mitochondrial respiratory activity in the kidneys of diabetic mice after STZ treatment ( Dugan et al., 2013 ); this suggests a loss...