Skip Nav Destination
Close Modal
Update search
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
NARROW
Format
Subjects
Journal
Article Type
TOC Section
Date
Availability
1-4 of 4
Keywords: Huntingtin
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Sort by
Journal Articles
Jocelynn R. Pearl, Amol C. Shetty, Jeffrey P. Cantle, Dani E. Bergey, Robert M. Bragg, Sydney R. Coffey, Holly B. Kordasiewicz, Leroy E. Hood, Nathan D. Price, Seth A. Ament, Jeffrey B. Carroll
Journal:
Disease Models & Mechanisms
Dis Model Mech dmm.052282.
Published: 10 April 2025
... of Huntington's disease (HD), the mechanistic basis remains poorly understood. Using chromatin immunoprecipitation and sequencing (ChIP-seq), we show that the huntingtin protein (HTT) reproducibly occupies specific locations in the mouse genome. Striatal HTT ChIP-seq peaks were enriched in coding regions of spiny...
Includes: Supplementary data
Journal Articles
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (6): dmm049447.
Published: 28 June 2022
... protein Period and its oscillations in young flies and a long-lasting rescue of the output neuropeptide Pigment dispersing factor. Significantly, there was a reduction in the expanded Huntingtin inclusion load, concomitant with the appearance of a spot-like Huntingtin form. Thus, we provide evidence...
Includes: Supplementary data
Journal Articles
Transgenic minipig model of Huntington's disease exhibiting gradually progressing neurodegeneration
Open AccessTaras Ardan, Monika Baxa, Božena Levinská, Miroslava Sedláčková, The Duong Nguyen, Jiří Klíma, Štefan Juhás, Jana Juhásová, Petra Šmatlíková, Petra Vochozková, Jan Motlík, Zdenka Ellederová
Journal:
Disease Models & Mechanisms
Dis Model Mech (2020) 13 (2): dmm041319.
Published: 12 December 2019
..., and compared them to wild-type animals. We were able to demonstrate not only an accumulation of different forms of mutant huntingtin (mHTT) in TgHD brain, but also pathological changes associated with cellular damage caused by mHTT. At 48 months, we detected pathological changes that included the demyelination...
Journal Articles
Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane
Open Access
Journal:
Disease Models & Mechanisms
Dis Model Mech (2014) 7 (12): 1335–1340.
Published: 1 December 2014
...Hemma Brandstaetter; Antonina J. Kruppa; Folma Buss Huntingtin is a large membrane-associated scaffolding protein that associates with endocytic and exocytic vesicles and modulates their trafficking along cytoskeletal tracks. Although the progression of Huntington’s disease is linked to toxic...
Includes: Supplementary data