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Keywords: Huntingtin
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Journal Articles
Dis Model Mech (2022) 15 (6): dmm049447.
Published: 28 June 2022
... protein Period and its oscillations in young flies and a long-lasting rescue of the output neuropeptide Pigment dispersing factor. Significantly, there was a reduction in the expanded Huntingtin inclusion load, concomitant with the appearance of a spot-like Huntingtin form. Thus, we provide evidence...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (2): dmm041319.
Published: 12 December 2019
..., and compared them to wild-type animals. We were able to demonstrate not only an accumulation of different forms of mutant huntingtin (mHTT) in TgHD brain, but also pathological changes associated with cellular damage caused by mHTT. At 48 months, we detected pathological changes that included the demyelination...
Journal Articles
Dis Model Mech (2014) 7 (12): 1335–1340.
Published: 1 December 2014
...Hemma Brandstaetter; Antonina J. Kruppa; Folma Buss Huntingtin is a large membrane-associated scaffolding protein that associates with endocytic and exocytic vesicles and modulates their trafficking along cytoskeletal tracks. Although the progression of Huntington’s disease is linked to toxic...
Includes: Supplementary data