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Keywords: Humanized mouse
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Journal Articles

Pre-existing antibody-mediated adverse effects prevent the clinical development of a bacterial anti-inflammatory protein

In collection:
Drug Discovery , Infectious disease biology
Angelino T. Tromp, Yuxi Zhao, Ilse Jongerius, Erik C. J. M. Heezius, Pauline Abrial, Maartje Ruyken, Jos A. G. van Strijp, Carla J. C. de Haas, András N. Spaan, Kok P. M. van Kessel, Thomas Henry, Pieter-Jan A. Haas
Journal: Disease Models & Mechanisms
Dis Model Mech (2020) 13 (9): dmm045534.
https://doi.org/10.1242/dmm.045534
Published: 28 September 2020
... responses in human-C5aR1 knock-in mice. Feasibility studies in a human phase I trial failed due to high levels of existing natural antibodies causing adverse effects. C5aR chemotaxis CHIPS Clinical trials Humanized mouse Immune complex Agence Nationale de la Recherche 10.13039...
View article titled, Pre-existing antibody-mediated adverse effects prevent the clinical development of a bacterial anti-inflammatory protein
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Includes: Supplementary data
Journal Articles

Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice

In collection:
Infectious disease biology , Microbiome in Health and Disease
Jocelyn M. Wessels, Julie Lajoie, Maeve I. J. Hay Cooper, Kenneth Omollo, Allison M. Felker, Danielle Vitali, Haley A. Dupont, Philip V. Nguyen, Kristen Mueller, Fatemeh Vahedi, Joshua Kimani, Julius Oyugi, Juliana Cheruiyot, John N. Mungai, Alexandre Deshiere, Michel J. Tremblay, Tony Mazzulli, Jennifer C. Stearns, Ali A. Ashkar, Keith R. Fowke, Michael G. Surette, Charu Kaushic
Journal: Disease Models & Mechanisms
Dis Model Mech (2019) 12 (10): dmm039669.
https://doi.org/10.1242/dmm.039669
Published: 23 October 2019
... colonization by lactobacilli, bacteria that are believed to protect against STIs. In a humanized mouse model, MPA treatment was associated with low serum estrogen, low glycogen and enhanced HIV-1 susceptibility. The mechanism by which the MPA-mediated changes in the vaginal microbiota may contribute to HIV-1...
View article titled, Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice
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Includes: Supplementary data
Journal Articles

Introduction of the human AVPR1A gene substantially alters brain receptor expression patterns and enhances aspects of social behavior in transgenic mice

Rhonda Charles, Takeshi Sakurai, Nagahide Takahashi, Gregory A. Elder, Miguel A. Gama Sosa, Larry J. Young, Joseph D. Buxbaum
Journal: Disease Models & Mechanisms
Dis Model Mech (2014) 7 (8): 1013–1022.
https://doi.org/10.1242/dmm.017053
Published: 1 August 2014
... This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. AVPR1A Humanized mouse...
View article titled, Introduction of the human AVPR1A gene substantially alters brain receptor expression patterns and enhances aspects of social behavior in transgenic mice
Open the PDF for Introduction of the human AVPR1A gene substantially alters brain receptor expression patterns and enhances aspects of social behavior in transgenic mice in another window
Includes: Supplementary data