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Keywords: Human induced pluripotent stem cells
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Journal Articles

Neurofibromin 1 mutations impair the function of human induced pluripotent stem cell-derived microglia

In collection:
Genetic Variance in Human Disease
Leonard D. Kuhrt, Edyta Motta, Nirmeen Elmadany, Hannah Weidling, Raphaela Fritsche-Guenther, Ibrahim E. Efe, Olivia Cobb, Jit Chatterjee, Lucy G. Boggs, Marina Schnauß, Sebastian Diecke, Marcus Semtner, Corina Anastasaki, David H. Gutmann, Helmut Kettenmann
Journal: Disease Models & Mechanisms
Dis Model Mech (2023) 16 (12): dmm049861.
https://doi.org/10.1242/dmm.049861
Published: 11 December 2023
... of human induced pluripotent stem cells to generate human microglia-like (hiMGL) cells heterozygous for three different NF1 gene mutations found in patients with NF1. Whereas all NF1 -mutant and isogenic control hiMGL cells expressed classical microglia markers and exhibited similar transcriptomes...
View article titled, Neurofibromin 1 mutations impair the function of <span class="search-highlight">human</span> <span class="search-highlight">induced</span> <span class="search-highlight">pluripotent</span> <span class="search-highlight">stem</span> <span class="search-highlight">cell</span>-derived microglia
Open the PDF for Neurofibromin 1 mutations impair the function of <span class="search-highlight">human</span> <span class="search-highlight">induced</span> <span class="search-highlight">pluripotent</span> <span class="search-highlight">stem</span> <span class="search-highlight">cell</span>-derived microglia in another window
Includes: Supplementary data
Journal Articles

High-throughput screen for compounds that modulate neurite growth of human induced pluripotent stem cell-derived neurons

Sean P. Sherman, Anne G. Bang
Journal: Disease Models & Mechanisms
Dis Model Mech (2018) 11 (2): dmm031906.
https://doi.org/10.1242/dmm.031906
Published: 2 February 2018
...Sean P. Sherman; Anne G. Bang ABSTRACT Development of technology platforms to perform compound screens of human induced pluripotent stem cell (hiPSC)-derived neurons with relatively high throughput is essential to realize their potential for drug discovery. Here, we demonstrate the feasibility...
View article titled, High-throughput screen for compounds that modulate neurite growth of <span class="search-highlight">human</span> <span class="search-highlight">induced</span> <span class="search-highlight">pluripotent</span> <span class="search-highlight">stem</span> <span class="search-highlight">cell</span>-derived neurons
Open the PDF for High-throughput screen for compounds that modulate neurite growth of <span class="search-highlight">human</span> <span class="search-highlight">induced</span> <span class="search-highlight">pluripotent</span> <span class="search-highlight">stem</span> <span class="search-highlight">cell</span>-derived neurons in another window
Includes: Supplementary data
Journal Articles

Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia

In collection:
Advanced in vitro models
Karim Si-Tayeb, Salam Idriss, Benoite Champon, Amandine Caillaud, Matthieu Pichelin, Lucie Arnaud, Patricia Lemarchand, Cédric Le May, Kazem Zibara, Bertrand Cariou
Journal: Disease Models & Mechanisms
Dis Model Mech (2016) 9 (1): 81–90.
https://doi.org/10.1242/dmm.022277
Published: 1 January 2016
... available cellular models preclude deciphering the consequences of PCSK9 mutation further. We aimed to validate urine-sample-derived human induced pluripotent stem cells (UhiPSCs) as an appropriate tool to model PCSK9-mediated ADH and FHBL. To achieve our goal, urine-sample-derived somatic cells were...
View article titled, Urine-sample-derived <span class="search-highlight">human</span> <span class="search-highlight">induced</span> <span class="search-highlight">pluripotent</span> <span class="search-highlight">stem</span> <span class="search-highlight">cells</span> as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia
Open the PDF for Urine-sample-derived <span class="search-highlight">human</span> <span class="search-highlight">induced</span> <span class="search-highlight">pluripotent</span> <span class="search-highlight">stem</span> <span class="search-highlight">cells</span> as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia in another window
Includes: Supplementary data