...-knockdown human embryonic stem cells (hESCs). Considering that spinal motor neurons are large cells that have a high energy demand, impaired mitochondrial function might be involved in the axonal defects and specific motor neuron degeneration in SMA. Spinal motor neurons have long axons, and the axonal...

... (OTX2) is frequently dysregulated in multiple MB variants; however, its role may be subtype specific. We recently demonstrated that neural precursors derived from transformed human embryonic stem cells (trans-hENs), but not their normal counterparts (hENs), resemble Groups 3 and 4 MB in vitro...