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Keywords: Human embryonic stem cells
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Journal Articles

Abnormal mitochondrial transport and morphology as early pathological changes in human models of spinal muscular atrophy

Open Access
In collection:
Advanced in vitro models , Neurodegenerative Disorders
Chong-Chong Xu, Kyle R. Denton, Zhi-Bo Wang, Xiaoqing Zhang, Xue-Jun Li
Journal: Disease Models & Mechanisms
Dis Model Mech (2016) 9 (1): 39–49.
https://doi.org/10.1242/dmm.021766
Published: 1 January 2016
.... A. and Zhang , S.-C. ( 2005 ). Specification of motoneurons from human embryonic stem cells . Nat. Biotechnol.   23 , 215 - 221 . doi:10.1038/nbt1063 Li , X.-J. , Hu , B.-Y. , Jones , S. A. , Zhang , Y.-S. , LaVaute , T. , Du , Z.-W. and Zhang , S.-C. ( 2008...
View articletitled, Abnormal mitochondrial transport and morphology as early pathological changes in human models of spinal muscular atrophy
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Includes: Supplementary data
Journal Articles

OTX2 exhibits cell-context-dependent effects on cellular and molecular properties of human embryonic neural precursors and medulloblastoma cells

Open Access
Ravinder Kaur, Christopher Aiken, Ludivine Coudière Morrison, Radhika Rao, Marc R. Del Bigio, Shravanti Rampalli, Tamra Werbowetski-Ogilvie
Journal: Disease Models & Mechanisms
Dis Model Mech (2015) 8 (10): 1295–1309.
https://doi.org/10.1242/dmm.020594
Published: 1 October 2015
... (OTX2) is frequently dysregulated in multiple MB variants; however, its role may be subtype specific. We recently demonstrated that neural precursors derived from transformed human embryonic stem cells (trans-hENs), but not their normal counterparts (hENs), resemble Groups 3 and 4 MB in vitro...
View articletitled, OTX2 exhibits cell-context-dependent effects on cellular and molecular properties of human embryonic neural precursors and medulloblastoma cells
Open the PDF for OTX2 exhibits cell-context-dependent effects on cellular and molecular properties of human embryonic neural precursors and medulloblastoma cells in another window
Includes: Supplementary data