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Keywords: High-throughput screening
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Journal Articles

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology

Open Access
In collection:
C. elegans as a Disease Model , Drug Discovery
Patricia K. Dranchak, Erin Oliphant, Bryan Queme, Laurence Lamy, Yuhong Wang, Ruili Huang, Menghang Xia, Dingyin Tao, James Inglese
Journal: Disease Models & Mechanisms
Dis Model Mech (2023) 16 (3): dmm049863.
https://doi.org/10.1242/dmm.049863
Published: 20 March 2023
...Patricia K. Dranchak; Erin Oliphant; Bryan Queme; Laurence Lamy; Yuhong Wang; Ruili Huang; Menghang Xia; Dingyin Tao; James Inglese ABSTRACT Quantitative high-throughput screening (qHTS) pharmacologically evaluates chemical libraries for therapeutic uses, toxicological risk and, increasingly...
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Includes: Supplementary data
Journal Articles

A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein

Open Access
In collection:
Drug Discovery , Infectious disease biology , Review Commons Transfers
Sabrina Yahiya, Charlie N. Saunders, Sarah Hassan, Ursula Straschil, Oliver J. Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J. Delves, Edward W. Tate, Anna Barnard, Matthew J. Fuchter, Jake Baum
Journal: Disease Models & Mechanisms
Series: REVIEW COMMONS TRANSFER
Dis Model Mech (2023) 16 (2): dmm049950.
https://doi.org/10.1242/dmm.049950
Published: 30 January 2023
... ). A high throughput screen for next-generation leads targeting malaria parasite transmission . Nat. Commun. 9 , 3805 . 10.1038/s41467-018-05777-2 Dziekan , J. M. , Wirjanata , G. , Dai , L. , Go , K. D. , Yu , H. , Lim , Y. T. , Chen , L. , Wang , L. C...
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Includes: Supplementary data
Journal Articles

High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva

Open Access
In collection:
Drug Discovery
Serena Cappato, Laura Tonachini, Francesca Giacopelli, Mario Tirone, Luis J. V. Galietta, Martina Sormani, Anna Giovenzana, Antonello E. Spinelli, Barbara Canciani, Silvia Brunelli, Roberto Ravazzolo, Renata Bocciardi
Journal: Disease Models & Mechanisms
Dis Model Mech (2016) 9 (6): 685–696.
https://doi.org/10.1242/dmm.023929
Published: 1 June 2016
... to prevent soft-tissue swelling (flare-ups) that trigger the ossification process. With the aim of finding a new therapeutic strategy for FOP, we developed a high-throughput screening (HTS) assay to identify inhibitors of ACVR1 gene expression among drugs already approved for the therapy of other diseases...
View articletitled, High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva
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Includes: Supplementary data