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Keywords: Hematopoietic stem cells
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Journal Articles
In collection:
The RAS Pathway
Xi Jin, Victor Ng, Meiling Zhao, Lu Liu, Tomoyasu Higashimoto, Zheng Hong Lee, Jooho Chung, Victor Chen, Gina Ney, Malathi Kandarpa, Moshe Talpaz, Qing Li
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (5): dmm049088.
Published: 6 May 2022
... to hematopoietic malignancies in mice. In murine hematopoietic stem cells (HSCs), mutant N-Ras G12D activates Stat5 to dysregulate stem cell function. However, the underlying mechanism remains elusive. In this study, we demonstrate that Stat5 activation induced by a hyperactive Nras mutant, G12D , is dependent...
Includes: Supplementary data
Journal Articles
Evisa Gjini, Chang-Bin Jing, Ashley T. Nguyen, Deepak Reyon, Emma Gans, Michiel Kesarsing, Joshua Peterson, Olga Pozdnyakova, Scott J. Rodig, Marc R. Mansour, Keith Joung, A. Thomas Look
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (5): dmm035790.
Published: 7 May 2019
... ) gene are common genetic abnormalities in human myeloid malignancies and induce clonal expansion of mutated hematopoietic stem cells (HSCs). To understand how ASXL1 disruption leads to myeloid cell transformation, we generated asxl1 haploinsufficient and null zebrafish lines using genome-editing...
Includes: Supplementary data