...; Florian Weinberger ABSTRACT Engineered heart tissue (EHT) transplantation represents an innovative, regenerative approach for heart failure patients. Late preclinical trials are underway, and a first clinical trial started recently. Preceding studies revealed functional recovery after implantation...

... stage to adulthood. Endoglin-deficient zebrafish develop cardiomegaly, resulting in heart failure and hypochromic anemia, which both stem from chronic hypoxia. endoglin mutant zebrafish display structural alterations of the developing gills and underlying vascular network that coincide with hypoxia...

...Kirsty Hooper; Julija Hmeljak ABSTRACT Heart failure affects ∼64 million people worldwide, resulting in high morbidity, mortality and societal cost. Current treatment strategies are primarily geared at slowing the progression to an advanced disease state, but do not reverse or cure heart failure...

... switching to pathogenic IgG2a and 2b autoantibodies in SLE . J. Exp. Med.   203 , 553 - 561 . 10.1084/jem.20052438 Eriksson , U. and Penninger , J. M. ( 2005 ). Autoimmune heart failure: new understandings of pathogenesis . Int. J. Biochem. Cell Biol.   37 , 27 - 32 . 10.1016/j.biocel...

...   138 , 3421 - 3430 . 10.1242/dev.068601 Wang , L. W. , Huttner , I. G. , Santiago , C. F. and Fatkin , D. ( 2016 ). Bradycardia in zebrafish heart failure: a true physiological response or anesthetic-induced red herring?   Zebrafish   13 , 475 - 476 . 10.1089/zeb.2016.1367...

...Jennifer L. Philip; Md. Abdur Razzaque; Mei Han; Jinju Li; Tiju Theccanat; Xianyao Xu; Shahab A. Akhter ABSTRACT Oxidative stress in cardiac fibroblasts (CFs) promotes transformation to myofibroblasts and collagen synthesis leading to myocardial fibrosis, a precursor to heart failure (HF). NADPH...