...; Florian Weinberger ABSTRACT Engineered heart tissue (EHT) transplantation represents an innovative, regenerative approach for heart failure patients. Late preclinical trials are underway, and a first clinical trial started recently. Preceding studies revealed functional recovery after implantation...

... stage to adulthood. Endoglin-deficient zebrafish develop cardiomegaly, resulting in heart failure and hypochromic anemia, which both stem from chronic hypoxia. endoglin mutant zebrafish display structural alterations of the developing gills and underlying vascular network that coincide with hypoxia...

...Kirsty Hooper; Julija Hmeljak ABSTRACT Heart failure affects ∼64 million people worldwide, resulting in high morbidity, mortality and societal cost. Current treatment strategies are primarily geared at slowing the progression to an advanced disease state, but do not reverse or cure heart failure...

... the heart, and their location determines the related functional impairment ( Voskuyl, 2006 ). Chronic inflammation also triggers the deposition of acute-phase protein amyloid, which can cause a range of pathologies, including conduction defects, cardiomegaly ( Box 1 ), cardiomyopathy and heart failure...

... parameters after 6 min of anesthesia, information obtained after this time is unreliable and image acquisition should ideally be completed within 3 min. Fish that are physiologically compromised as a result of disease (e.g. heart failure) display a significant time-dependent decrement in heart rate...

...Jennifer L. Philip; Md. Abdur Razzaque; Mei Han; Jinju Li; Tiju Theccanat; Xianyao Xu; Shahab A. Akhter ABSTRACT Oxidative stress in cardiac fibroblasts (CFs) promotes transformation to myofibroblasts and collagen synthesis leading to myocardial fibrosis, a precursor to heart failure (HF). NADPH...