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Keywords: Hearing loss
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Journal Articles
Dis Model Mech (2021) 14 (2): dmm047225.
Published: 14 February 2021
...Morag A. Lewis; Francesca Di Domenico; Neil J. Ingham; Haydn M. Prosser; Karen P. Steel ABSTRACT The microRNA miR-96 is important for hearing, as point mutations in humans and mice result in dominant progressive hearing loss. Mir96 is expressed in sensory cells along with Mir182 and Mir183...
Includes: Supplementary data
Journal Articles
Journal Articles
Dis Model Mech (2019) 12 (12): dmm040170.
Published: 20 December 2019
... for Ak2 deficiencies. One of the clinical features of RD is hearing loss, but its pathophysiology and causes have not been determined. In adult mammals, sensory hair cells of the inner ear do not regenerate; however, their regeneration has been observed in several non-mammalian vertebrates, including...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (2): dmm033019.
Published: 26 February 2018
...Sen Chen; Le Xie; Kai Xu; Hai-Yan Cao; Xia Wu; Xiao-Xiang Xu; Yu Sun; Wei-Jia Kong ABSTRACT Mutations in the GJB2 gene [which encodes connexin 26 (Cx26)] are the most common causes of hereditary hearing loss in humans, and previous studies showed postnatal development arrest of the organ of Corti...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (12): 1543–1553.
Published: 1 December 2015
... and p38. In humans, mutant alleles of MAP3K1 are associated with 46,XY sex reversal. Until recently, the only phenotype observed in Map3k1 tm1Yxia mutant mice was open eyelids at birth. Here, we report that homozygous Map3k1 tm1Yxia mice have early-onset profound hearing loss accompanied...
Includes: Supplementary data
Journal Articles