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Alexa Burger, Aleksandr Vasilyev, Ritu Tomar, Martin K. Selig, G. Petur Nielsen, Randall T. Peterson, Iain A. Drummond, Daniel A. Haber
Journal: Disease Models & Mechanisms
Dis Model Mech (2014) 7 (7): 907–913.
Published: 1 July 2014
... identified, activation of EGFR and downstream AKT-PI3K pathways have been described. Here, we report a zebrafish model of chordoma, based on stable transgene-driven expression of HRASV12 in notochord cells during development. Extensive intra-notochordal tumor formation is evident within days of transgene...
Includes: Supplementary data