... remain elusive. To date, little is known on the behaviour of individual hypoxic tumour cells in their microenvironment. To explore this issue in a spatial and temporally controlled manner, we developed a genetically encoded sensor by fusing the O 2 -labile hypoxia-inducible factor 1α (HIF-1α) protein...

... of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Sirtuins MYC HIF Warburg effect Metabolic reprogramming The sirtuins...