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Keywords: HD large animal model
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Journal Articles

Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease

In collection:
Rare Disease Translational Research
Marie Rodinova, Jana Krizova, Hana Stufkova, Bozena Bohuslavova, Georgina Askeland, Zaneta Dosoudilova, Stefan Juhas, Jana Juhasova, Zdenka Ellederova, Jiri Zeman, Lars Eide, Jan Motlik, Hana Hansikova
Journal: Disease Models & Mechanisms
Dis Model Mech (2019) 12 (7): dmm038737.
https://doi.org/10.1242/dmm.038737
Published: 26 July 2019
... of disease progression and suggest that similar pathogenic mechanisms underlie disease progression in TgHD minipigs and HD patients. Huntington's disease Mitochondrial function Ultrastructure HD large animal model Disease development Skeletal muscle Biomarkers Charles University...
View article titled, Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease
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Journal Articles

A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies

In collection:
Neurodegenerative Disorders
Georgina Askeland, Marie Rodinova, Hana Štufková, Zaneta Dosoudilova, Monika Baxa, Petra Smatlikova, Bozena Bohuslavova, Jiri Klempir, The Duong Nguyen, Anna Kuśnierczyk, Magnar Bjørås, Arne Klungland, Hana Hansikova, Zdenka Ellederova, Lars Eide
Journal: Disease Models & Mechanisms
Dis Model Mech (2018) 11 (10): dmm035949.
https://doi.org/10.1242/dmm.035949
Published: 24 October 2018
... DNA damage DNA repair HD large animal model Norges Forskningsråd MSMT-28477/2014 Ministerstvo Školství, Mládeže a Tělovýchovy COST LD15099 LO1609 Univerzita Karlova v Praze 10.13039/100007397 PROGRES Q26/LF1/3 Helse Midt-Norge 10.13039/501100004590...
View article titled, A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
Open the PDF for A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies in another window
Includes: Supplementary data