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Keywords: GnRH neuron
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Journal Articles

FGF8–FGFR1 signaling regulates human GnRH neuron differentiation in a time- and dose-dependent manner

In collection:
Advanced in vitro models
Venkatram Yellapragada, Nazli Eskici, Yafei Wang, Shrinidhi Madhusudan, Kirsi Vaaralahti, Timo Tuuri, Taneli Raivio
Journal: Disease Models & Mechanisms
Dis Model Mech (2022) 15 (8): dmm049436.
https://doi.org/10.1242/dmm.049436
Published: 16 August 2022
...-expressing neurons (GnRH neurons). We hypothesized that FGF8 regulates differentiation of human GnRH neurons in a time- and dose-dependent manner via FGFR1. To investigate this further, human pluripotent stem cells were differentiated during 10 days of dual-SMAD inhibition into neural progenitor cells...
View article titled, FGF8–FGFR1 signaling regulates human <span class="search-highlight">GnRH</span> <span class="search-highlight">neuron</span> differentiation in a time- and dose-dependent manner
Open the PDF for FGF8–FGFR1 signaling regulates human <span class="search-highlight">GnRH</span> <span class="search-highlight">neuron</span> differentiation in a time- and dose-dependent manner in another window
Includes: Supplementary data
Journal Articles

Characterization of the human GnRH neuron developmental transcriptome using a GNRH1 -TdTomato reporter line in human pluripotent stem cells

In collection:
Advanced in vitro models
Carina Lund, Venkatram Yellapragada, Sanna Vuoristo, Diego Balboa, Sara Trova, Cecile Allet, Nazli Eskici, Kristiina Pulli, Paolo Giacobini, Timo Tuuri, Taneli Raivio
Journal: Disease Models & Mechanisms
Dis Model Mech (2020) 13 (3): dmm040105.
https://doi.org/10.1242/dmm.040105
Published: 13 March 2020
...Carina Lund; Venkatram Yellapragada; Sanna Vuoristo; Diego Balboa; Sara Trova; Cecile Allet; Nazli Eskici; Kristiina Pulli; Paolo Giacobini; Timo Tuuri; Taneli Raivio ABSTRACT Gonadotropin-releasing hormone (GnRH) neurons provide a fundamental signal for the onset of puberty and subsequent...
View article titled, Characterization of the human <span class="search-highlight">GnRH</span> <span class="search-highlight">neuron</span> developmental transcriptome using a GNRH1 -TdTomato reporter line in human pluripotent stem cells
Open the PDF for Characterization of the human <span class="search-highlight">GnRH</span> <span class="search-highlight">neuron</span> developmental transcriptome using a GNRH1 -TdTomato reporter line in human pluripotent stem cells in another window
Includes: Supplementary data