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Keywords: Glutamine fructose-6-phosphate transaminase 1 (GFPT1)
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Journal Articles

Muscle-specific lack of Gfpt1 triggers ER stress to alleviate misfolded protein accumulation

In collection:
Neuromuscular Disease , Rare Disease Translational Research
Ruchen Zhang, Paniz Farshadyeganeh, Bisei Ohkawara, Kazuki Nakajima, Jun-ichi Takeda, Mikako Ito, Shaochuan Zhang, Yuki Miyasaka, Tamio Ohno, Madoka Mori-Yoshimura, Akio Masuda, Kinji Ohno
Journal: Disease Models & Mechanisms
Dis Model Mech (2024) 17 (8): dmm050768.
https://doi.org/10.1242/dmm.050768
Published: 25 July 2024
... that the original work is properly attributed. GFPT1 encodes glutamine fructose-6-phosphate transaminase 1 (GFPT1), which is the first and rate-limiting enzyme of the hexosamine biosynthesis pathway (HBP) to produce uridine diphosphate (UDP) N -acetylglucosamine (UDP-GlcNAc), a substrate for N - and O...
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Includes: Supplementary data