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Keywords: Glutamate dehydrogenase
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Journal Articles
Leonie Drews, Marcel Zimmermann, Philipp Westhoff, Dominik Brilhaus, Rebecca E. Poss, Laura Bergmann, Constanze Wiek, Peter Brenneisen, Roland P. Piekorz, Tabea Mettler-Altmann, Andreas P. M. Weber, Andreas S. Reichert
Journal:
Disease Models & Mechanisms
Dis Model Mech (2020) 13 (10): dmm047134.
Published: 4 November 2020
... ammonia showed rapid incorporation of 15 N into glutamate and glutamate-derived amino acids. Downregulating human GLUD2 [encoding mitochondrial glutamate dehydrogenase 2 (GDH2)], inhibiting GDH2 activity by SIRT4 overexpression, and supplementing cells with glutamate or glutamine alleviated ammonia...
Includes: Supplementary data