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Keywords: Genetic screen
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Journal Articles

Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome

Open Access
In collection:
Developmental Disorders
Anna J. Moyer, Fabian-Xosé Fernandez, Yicong Li, Donna K. Klinedinst, Liliana D. Florea, Yasuhiro Kazuki, Mitsuo Oshimura, Roger H. Reeves
Journal: Disease Models & Mechanisms
Dis Model Mech (2023) 16 (4): dmm049712.
https://doi.org/10.1242/dmm.049712
Published: 13 April 2023
... http://dx.doi.org/10.13039/100012304 National Institutes of Health http://dx.doi.org/10.13039/100000002 5R01HD038384 F31HD098826 5R21HD082614 U54HD079123 Down syndrome Sonic hedgehog Aneuploidy Gene dosage effects Genetic screen Trisomy 21 Summary: Human...
View articletitled, Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome
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Includes: Supplementary data
Journal Articles

A genetic screen in Drosophila reveals the role of fucosylation in host susceptibility to Candida infection

Open Access
In collection:
Drosophila as a Disease Model , Infectious disease biology
Marcus T. Glittenberg, Ilias Kounatidis, Magda Atilano, Petros Ligoxygakis
Journal: Disease Models & Mechanisms
Dis Model Mech (2022) 15 (5): dmm049218.
https://doi.org/10.1242/dmm.049218
Published: 9 May 2022
... certain disadvantages in that obtaining results is time-consuming, owing to relatively long lifespans, and these results have low statistical resolution because sample sizes are usually small. Here, we report a targeted genetic screening of 5698 RNAi lines encompassing 4135 Drosophila genes with human...
View articletitled, A genetic screen in Drosophila reveals the role of fucosylation in host susceptibility to Candida infection
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Includes: Supplementary data
Journal Articles

Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE

Open Access
In collection:
Drug Discovery
Lucía F. Zacchi, John C. Dittmar, Michael J. Mihalevic, Annette M. Shewan, Benjamin L. Schulz, Jeffrey L. Brodsky, Kara A. Bernstein
Journal: Disease Models & Mechanisms
Dis Model Mech (2017) 10 (9): 1129–1140.
https://doi.org/10.1242/dmm.029926
Published: 1 September 2017
... Genetic screen Protein levels Protein disulfide isomerase TorsinA Dystonia Dystonia is a movement disorder characterized by sustained involuntary muscle contractions leading to abnormal, often repetitive movements and/or postures ( Albanese et al., 2013 ). One of the most severe types...
View articletitled, Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE
Open the PDF for Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE in another window
Includes: Supplementary data