... to Ts66Yah, presumably due to the trisomy of the centromeric region of Mmu17. Altogether, the results from learning and behavior, craniofacial and brain morphologies, and gene expression in two brain regions highlighted the interference of the Scaf8-Pde10a trisomy in the Ts65Dn phenotypes. Considering...

... identified that correlated in the developmentally induced MM and RCC, including components of the caveolar-mediated endocytosis signaling pathway. An efficient siRNA-mediated knockdown (KD) of Bnip3 , Gsn , Lgals3 , Pax8 , Cav1 , Egfr or Itgb2 gene expression was achieved in mouse RCC (Renca) cells. The live...

... presented with an absent or localised expression pattern (categorised as 0-10 positive structures). A link between complexity of expression profile and viability of homozygous null animals was observed; inactivation of genes expressed in ≥21 structures was more likely to result in reduced viability...

... the usefulness of lacZ in situ reporter expression patterns in extending our understanding of genotype-phenotype relationships as part of the IMPC high-throughput screen. In situ gene expression profiling is invaluable for evaluating compartment-specific gene expression patterns, and these enrich our...