... investigated how manipulating the expression of Tribbles impacts body weight, sleep and mortality. We showed that the overexpression of Drosophila tribbles ( trbl ) in the fly fat body reduces both body weight and lifespan in adult flies without affecting food intake. Furthermore, it decreases the levels...

... pathways) induce the synthesis of antimicrobial peptides (AMPs) within the fat body. Recently, it has been reported that certain cationic AMPs exhibit selective cytotoxicity against human cancer cells; however, little is known about their anti-tumour effects. Drosophila mxc mbn1 mutants exhibit malignant...

..., numerous studies can now be performed in flies to more rapidly discover the molecular mechanisms by which human mutations cause disease phenotypes. Drosophila Human disease models Nervous system Neurodegeneration Regeneration Heart Liver Oenocyte Fat body Kidney Nephrocytes Malpighian...