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Keywords: Eye development
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Journal Articles

frizzled 5 mutant zebrafish are genetically sensitised to developing microphthalmia and coloboma

Open Access
In collection:
Zebrafish as a Disease Model
Clinton Monfries, Stephen Carter, Paris Ataliotis, Aya Bseisu, Mahum Shaikh, Maria Hernández-Bejarano, Mohammed Fourteia, Mara Ioana Maftei, Rodrigo M. Young, Stephen W. Wilson, Gaia Gestri, Florencia Cavodeassi
Journal: Disease Models & Mechanisms
Dis Model Mech (2025) 18 (6): dmm052284.
https://doi.org/10.1242/dmm.052284
Published: 10 June 2025
... of additional genes associated with ocular malformations. Thus, eye development can occur normally in the absence of Fzd5 in zebrafish, but mutants are sensitised to developing eye malformations. By exploiting the sensitised nature of the fzd5 mutants, we further identified angio-associated migratory cell...
View article titled, frizzled 5 mutant zebrafish are genetically sensitised to developing microphthalmia and coloboma
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Includes: Supplementary data
Journal Articles

A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8

Open Access
In collection:
Drosophila as a Disease Model
Dimitrije Stanković, Ann-Katrin Claudius, Thomas Schertel, Tina Bresser, Mirka Uhlirova
Journal: Disease Models & Mechanisms
Dis Model Mech (2020) 13 (6): dmm043174.
https://doi.org/10.1242/dmm.043174
Published: 26 June 2020
... underlying the loss of tissue homeostasis and degeneration caused by mutations in the core component of the spliceosome Prp8. Drosophila Prp8 Retinitis pigmentosa Apoptosis Eye development Splicing factor Fritz Thyssen Foundation 10.13039/501100003390 10.15.1.022MN Center...
View article titled, A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8
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Includes: Supplementary data
Journal Articles

Zika virus non-structural protein NS4A restricts eye growth in Drosophila through regulation of JAK/STAT signaling

Open Access
In collection:
Drosophila as a Disease Model , Infectious disease biology
Sneh Harsh, Yulong Fu, Eric Kenney, Zhe Han, Ioannis Eleftherianos
Journal: Disease Models & Mechanisms
Dis Model Mech (2020) 13 (4): dmm040816.
https://doi.org/10.1242/dmm.040816
Published: 30 April 2020
.... Summary: Our study provides evidence that Zika virus infection in Drosophila results in restricted growth of the developing eye and wing through regulation of JAK/STAT and Notch signaling, respectively. Drosophila Eye development JAK/STAT signaling Host-pathogen interaction Zika virus...
View article titled, Zika virus non-structural protein NS4A restricts eye growth in Drosophila through regulation of JAK/STAT signaling
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Includes: Supplementary data