... that the original work is properly attributed. Summary:   Slc26a2 -mediated sulfate metabolism plays a critical role in tooth development, with deficiencies leading to disrupted odontoblast differentiation and downregulation of Wnt signaling. Tooth development Odontoblasts Extracellular matrix...

... cancer cells and the microenvironments they encounter at secondary sites. Two emerging concepts concerning the biology of metastasis are that organ-specific microenvironments influence the fate of disseminated cancer cells, and that cancer cell-extracellular matrix interactions have important roles...

... in extracellular matrix (ECM) conformation and mineralisation coupled to vascular changes, which are augmented in males. Whether this phenotypic dimorphism arises as a result of the divergent control of ECM composition and its subsequent arrangement is unknown and is the focus of this study. Herein, we used murine...

... disease, we showed that missorting of a number of lysosomal enzymes is associated with intracellular accumulation of chondroitin sulfate in Gnptg ko chondrocytes and their impaired differentiation, as well as with altered microstructure of the cartilage extracellular matrix (ECM). We also demonstrated...

...Alec R. Nickolls; Michelle M. Lee; Kristen Zukosky; Barbara S. Mallon; Carsten G. Bönnemann ABSTRACT The basal lamina is a specialized sheet of dense extracellular matrix (ECM) linked to the plasma membrane of specific cell types in their tissue context, which serves as a structural scaffold...

... of the extracellular matrix [i.e. collagen cross-linking mediated by the lysyl oxidase (LO) family of enzymes (LOX, LOXL1-4)] might contribute to disease pathogenesis and represent a therapeutic target. This study aimed to further our understanding of the mechanisms by which LO inhibitors might improve lung fibrosis...

... is a major component of the basement membrane (BM), a specialised extracellular matrix structure that provides structural support and influences cell behaviour and signalling. Vertebrates express six collagen IV alpha chains, Col4a1-Col4a6 , and in the endoplasmic reticulum (ER) three alpha chains form...

...María Miana; María Galán; Ernesto Martínez-Martínez; Saray Varona; Raquel Jurado-López; Belén Bausa-Miranda; Alfonso Antequera; María Luaces; José Martínez-González; Cristina Rodríguez; Victoria Cachofeiro ABSTRACT Extracellular matrix (ECM) remodelling of the adipose tissue plays a pivotal role...

... directly to FBN2 with an affinity comparable to FBN1. The observed extracellular matrix (ECM) alterations were associated with increased bronchial epithelial TGFβ signaling at 17.5 days of gestation; however, treatment with TGFβ-neutralizing antibody did not correct the epithelial dysplasia...

... that at least Ltbp-4L expression is essential for incorporation of fibulin-4 into the extracellular matrix (ECM). Overall, our results contribute to the current understanding of elastogenesis and provide an animal model of ARCL1C. Protein expression levels were determined by western blotting, using SDS...

... Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Elastic fibers Extracellular matrix Aortic valve Fibrosis Angiogenesis Aortic valve disease...

...Matthew Giannandrea; William C. Parks ABSTRACT Fibrosis – a debilitating condition that can occur in most organs – is characterized by excess deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of proteinases that can degrade matrix, such as matrix...