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Keywords: Ethanol
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Journal Articles

Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation

Open Access
In collection:
Cancer Metabolism
Guia Cerretelli, Ying Zhou, Mike F. Müller, David J. Adams, Mark J. Arends
Journal: Disease Models & Mechanisms
Dis Model Mech (2023) 16 (8): dmm050240.
https://doi.org/10.1242/dmm.050240
Published: 31 July 2023
... with Aldh1b1 inactivation. Conditional (Aldh1b1 flox/flox ) or constitutive (Aldh1b1 −/− ) Aldh1b1 knockout alleles combined with the conditional Msh2 flox/− intestinal knockout mouse model of LS (Msh2-LS) received either ethanol, which is metabolised to acetaldehyde, or water. We demonstrated that 41.7...
View articletitled, Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation
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Includes: Supplementary data
Journal Articles

Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish

Open Access
In collection:
Zebrafish as a Disease Model
Kathryn Bambino, Chi Zhang, Christine Austin, Chitra Amarasiriwardena, Manish Arora, Jaime Chu, Kirsten C. Sadler
Journal: Disease Models & Mechanisms
Dis Model Mech (2018) 11 (2): dmm031575.
https://doi.org/10.1242/dmm.031575
Published: 26 February 2018
.... Here, we examined the contribution of iAs to FLD using zebrafish and tested the interaction with ethanol to cause alcoholic liver disease (ALD). We report that zebrafish exposed to iAs throughout development developed specific phenotypes beginning at 4 days post-fertilization (dpf), including...
View articletitled, Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish
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Includes: Supplementary data
Journal Articles

Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia

Open Access
Benjamin M. Kahn, Tanya S. Corman, Korah Lovelace, Mingi Hong, Robert S. Krauss, Douglas J. Epstein
Journal: Disease Models & Mechanisms
Dis Model Mech (2017) 10 (1): 29–37.
https://doi.org/10.1242/dmm.026195
Published: 1 January 2017
... genes and prenatal ethanol exposure. Mouse embryos with mutations in the Shh co-receptor, Cdon , were treated in utero with ethanol or saline at embryonic day 8 (E8.0) and evaluated for optic nerve hypoplasia (ONH), a prominent feature of SOD. We show that both Cdon −/− mutation and prenatal ethanol...
View articletitled, Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia
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