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Keywords: Epithelial integrity
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Journal Articles
In collection:
Infectious disease biology
Vlasta Lungova, Madhu Gowda, Jessica M. Fernandez, Stephanie Bartley, Anumitha Venkatraman, Federico E. Rey, Susan L. Thibeault
Journal:
Disease Models & Mechanisms
Dis Model Mech (2024) 17 (7): dmm050670.
Published: 16 July 2024
... at the cellular, molecular and ultrastructural levels. Our findings demonstrate that SP disrupts VF epithelial integrity and initiates inflammation via the exported products HtrA1 and pneumolysin. In contrast, SS attaches to the VF epithelium, reduces inflammation and induces Mmp2-mediated apical desquamation...
Includes: Supplementary data
