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Keywords: Epithelial barrier
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Journal Articles

Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease

In collection:
Zebrafish as a Disease Model
Ling-shiang Chuang, Joshua Morrison, Nai-yun Hsu, Philippe Ronel Labrias, Shikha Nayar, Ernie Chen, Nicole Villaverde, Jody Ann Facey, Gilles Boschetti, Mamta Giri, Mireia Castillo-Martin, Tin Htwe Thin, Yashoda Sharma, Jaime Chu, Judy H. Cho
Journal: Disease Models & Mechanisms
Dis Model Mech (2019) 12 (8): dmm037432.
https://doi.org/10.1242/dmm.037432
Published: 13 August 2019
..., the effects on epithelial barrier function and intestinal autophagy of one-course and repetitive injury. Repetitive injury induces increased mortality, impaired recovery of intestinal barrier function, failure to contain bacteria within the intestine and impaired autophagy. Prostaglandin E2 (PGE2...
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Includes: Supplementary data
Journal Articles

Paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling

Jessica R. White, Huiyu Gong, Brock Pope, Patrick Schlievert, Steven J. McElroy
Journal: Disease Models & Mechanisms
Dis Model Mech (2017) 10 (6): 727–736.
https://doi.org/10.1242/dmm.028589
Published: 1 June 2017
... pathogenesis. Paneth cells play critical roles in epithelial homeostasis, innate immunity and host-microbial interactions. Yet, the complex interplay between Paneth cell disruption, epithelial barrier dysfunction and microbial-driven inflammation remains unclear in the immature intestine. In this study...
View article titled, Paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling
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