...Jocelynn R. Pearl; Amol C. Shetty; Jeffrey P. Cantle; Dani E. Bergey; Robert M. Bragg; Sydney R. Coffey; Holly B. Kordasiewicz; Leroy E. Hood; Nathan D. Price; Seth A. Ament; Jeffrey B. Carroll While progressive striatal gene expression changes and epigenetic alterations are a prominent feature...

... expression promotes in vitro transformation in a 3D breast cancer model through widespread increase in chromatin accessibility and the acquisition of stem-like phenotype. Breast Cancer Chromatin Epigenetics In vitro Stem Leverhulme Trust http://dx.doi.org/10.13039/501100000275...

... different ages. Furthermore, epigenetic control was observed in mouse and human cultured cell lines. In amyotrophic lateral sclerosis, the formation of TDP-43-containing brain inclusions removes functional protein from the system. This phenomenon is continuous but compensated by newly synthesized protein...

... regulators of malignant transformation in cancer, we reveal how knowledge gained from the field of cancer has aided our understanding in how metabolism likewise controls neural fate determination and stability by directly wiring into the cellular epigenetic landscape. We further summarize research pertaining...

... adhesion molecules, transcription factors, epigenetic regulators and other morphogenetic signaling pathways, including the Bmp, Fgf, Tgfβ, Shh and retinoic acid pathways, in orofacial clefts in humans and animal models, which may provide a better understanding of these disorders and could be applied...

...Carmen Hurtado del Pozo; Elena Garreta; Juan Carlos Izpisúa Belmonte; Nuria Montserrat ABSTRACT Understanding epigenetic mechanisms is crucial to our comprehension of gene regulation in development and disease. In the past decades, different studies have shown the role of epigenetic modifications...

... therapies. DNA methylation is vitally important for establishing stable epigenetic states during mammalian development ( Rinaldi and Benitah, 2015 ; Seisenberger et al., 2012 ; Watanabe et al., 2002 ). However, in cancer cells, large regions of methylated DNA are hypermethylated, whereas others show...

.... Summary: We review genetic models of obesity, their optogenetic and chemogenetic successors, and the use of dietary manipulations and meal-feeding regimes. Binge eating Epigenetics Obesity Transgenics Scottish Government 266408 Biotechnology and Biological Sciences Research...

... divining rod points to oxidative stress . Mol. Cell   42 , 561 - 568 . 10.1016/j.molcel.2011.05.008 Berdasco , M. and Esteller , M. ( 2010 ). Aberrant epigenetic landscape in cancer: how cellular identity goes awry . Dev. Cell   19 , 698 - 711 . 10.1016/j.devcel.2010.10.005...