... (TGF-β) signaling in endothelial cells. This disorder is characterized by arteriovenous malformations that are prone to rupture, and the ensuing hemorrhages are responsible for iron-deficiency anemia. Along with activin receptor-like kinase ( ALK1 ), mutations in endoglin are associated with the vast...

... on the upright microscope imaging chamber as shown in Fig. 1 J,K. A LaVision Biotec Trimscope II double-header custom multi-photon microscope was used for laser wounding of brain endothelial cells. This was achieved with a Mai Tai HP Ti:Sapphire laser at 785 nm at 50% power and a Zeiss PlanApo 2×water 1.0 N.A...

... in atherosclerotic aortas. Furthermore, en face lesion area was increased in macrophage- and endothelial-specific deletions of Ripk3 in the descending and abdominal regions of the aorta . Analysis of bone-marrow-derived macrophages and cultured endothelial cells revealed that Ripk3 deletion promotes expression...

.... Interestingly, a circulating form of endoglin (also known as soluble endoglin, sEng), proteolytically released from the membrane-bound protein and displaying antiangiogenic activity, has been described in several endothelial-related pathological conditions. Using human and mouse endothelial cells, we find...

..., and showed strongly reduced mRNA and protein levels for Hif-2α and VEGF; such reduced levels are associated with embryonic endothelial cell apoptosis and lung bleedings. Betamethasone injection in pregnant females prevented respiratory failure in KLEIP −/− neonates, normalized lung maturation...