... . 10.1016/j.stemcr.2019.06.004 Hansen , A. , Eder , A. , Bonstrup , M. , Flato , M. , Mewe , M. , Schaaf , S. , Aksehirlioglu , B. , Schwoerer , A. P. , Uebeler , J. and Eschenhagen , T. ( 2010 ). Development of a drug screening platform based on engineered...

... active compounds exhibited activity in the zebrafish-infection model. Our initial drug screen was based on a single concentration (10 µM) in order to rapidly screen and select highly active compounds. Therefore, the screen is not sensitive enough to identify drugs that are active at higher concentrations...

...-throughput drug screens have been useful in identifying potential therapeutic compounds; however, current preclinical testing is time and labor intensive. Thus, development of a high-capacity in vivo platform suitable for screening candidate drugs/compounds would be valuable for compound optimization...

... anthraquinones were identified as bone dyes in live vertebrates, and two chemotherapeutic drugs were shown to have distinct preferences for the liver. Zebrafish Drug screening Bone staining Hyperplasia Purpurin Epirubicin Due to their small size, optical transparency, high fecundity...

... and secondary drug screening assays for Friedreich ataxia . J. Biomol. Screen   17 , 303 - 313 . 10.1177/1087057111427949 Couplan , E. , Aiyar , R. S. , Kucharczyk , R. , Kabala , A. , Ezkurdia , N. , Gagneur , J. , St Onge , R. P. , Salin , B. , Soubigou , F. , Le...

.... Summary: We have developed a phenotype-driven screen for identifying new inhibitors of collective cell migration and demonstrated the screen can successfully identify compounds active in vivo and potentially new pathways for targeting cancer metastasis. Drug screening Metastasis Orthotopic...

... for xenotransplantation studies means that the zebrafish can serve as an early preclinical drug screening tool and can also help personalize cancer therapy by providing real-time data on the response of the human cells to treatment. In this Review, we summarize the use of zebrafish embryos in drug screening and highlight...