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Keywords: Drug resistance
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Journal Articles
Journal Articles
Dis Model Mech (2022) 15 (5): dmm049401.
Published: 9 May 2022
...-based drug pellets that are consumed voluntarily. We applied this to zebrafish with BRAF-mutant melanoma, a model that has significantly advanced our understanding of melanoma progression, but not of drug resistance due to the limitations of current treatment methods. Zebrafish with melanomas responded...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (2): dmm049280.
Published: 11 February 2022
... cellular stress adaptation and how this functions in drug resistance is of vital importance for identifying new therapeutic targets and therapeutic combinations to treat RAS-driven cancers. American Cancer Society http://dx.doi.org/10.13039/100000048 130042-IRG-16-244-10-IRG Margaret Q...
Journal Articles
Dis Model Mech (2022) 15 (2): dmm049148.
Published: 4 January 2022
... with atorvastatin. Here, we show that atorvastatin suppresses premalignant disease by inhibiting the recruitment of pro-tumourigenic macrophages to the tumour microenvironment, manifested in part by suppression of Rac-mediated CCR1 ligand secretion. However, prolonged atorvastatin treatment leads to drug resistance...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (12): dmm040717.
Published: 19 December 2019
... for malaria elimination is the development of antimalarial drug resistance. Ineffective treatment regimens will fail to remove the circulating parasites and to prevent the local transmission of the disease. Genomic epidemiology of malaria parasites has become a powerful tool to track emerging drug-resistant...