... of human muscle diseases. Through improved standardization and harmonization of drug screening parameters and protocols, we aim to promote more effective drug discovery programs. References AINCSNS ( 1977 ). Report of the American institute of nutrition Ad Hoc committee on standards for nutritional...

... collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS) . Curr. Top. Med. Chem. 14 , 340 - 342 . 10.2174/1568026613666131127160819 Ewbank , J. J. and Zugasti , O. ( 2011 ). C. elegans: model host and tool for antimicrobial drug discovery . Dis...

...]-sulphonamide scaffold potently prevents malaria parasite transmission to the mosquito by targeting the Plasmodium falciparum vacuole membrane protein Pfs16. Plasmodium falciparum Malaria High-throughput screening Target identification Target validation Transmission Drug discovery...

... , S. , Adatto , I. , Freeman , J. L. , Gamse , J. T. , Iturria , I. , Lawrence , C. , Muriana , A. , Peterson , R. T. , Van Cruchten , S. and Zon , L. I. ( 2020 ). Use of Zebrafish in drug discovery toxicology . Chem. Res. Toxicol. 33 , 95 - 118...

... with pharmaceutical potential in vivo ( Corman et al., 2019 ; McGown et al., 2016 ). Drug discovery Phenotypic screening Chondrolectin VAST Zebrafish Synapse stabilization Summary: We report an automated and high-throughput screening platform to identify compounds relevant to motor neuron...

... provided that the original work is properly attributed. Summary: A zebrafish screen identifies a novel PPARα/γ ligand, idebenone, with potential for treatment of fatty liver diseases, as seen by testing it in a mouse model of type 2 diabetes. Drug discovery Fatty liver disease Idebenone...

... the organization of the nervous system, its component neurotransmitters and potential for drug discovery. Using synapsin as a neuronal marker, we map the central and peripheral nervous systems in the Schistosoma mansoni adult and schistosomulum (post-infective larva). We discover the widespread presence...

... and reproduction in any medium provided that the original work is properly attributed. Drug Discovery Collection: This Review discusses GEMMs of human pancreatic cancer, particularly focusing on the KPC model, its use in preclinical research, advantages and disadvantages, and its potential for predicting...

... treatment and, potentially, drug discovery for the broader heart-failure population. Similarly, a zebrafish model has been created to simulate amyloid light-chain amyloidosis, a plasma cell disorder that causes rapidly progressive cardiomyopathy ( Mishra et al., 2013 ). Direct injection of human amyloid...

... animal models for the study of pathological mechanisms of MNDs and are particularly advantageous for the screening of compounds with therapeutic potential. We present an overview of their potential usefulness in MND drug discovery, which is just beginning and holds much promise for future therapeutic...