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Keywords: Drosophila model
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Journal Articles

A Drosophila model targets Eiger/TNFα to alleviate obesity-related insulin resistance and macrophage infiltration

In collection:
Metabolic Disorders
Zhasmine Mirzoyan, Alice Valenza, Sheri Zola, Carola Bonfanti, Lorenzo Arnaboldi, Nicholas Ferrari, John Pollard, Valeria Lupi, Matteo Cassinelli, Matteo Frattaroli, Mehtap Sahin, Maria Enrica Pasini, Paola Bellosta
Journal: Disease Models & Mechanisms
Dis Model Mech (2023) 16 (11): dmm050388.
https://doi.org/10.1242/dmm.050388
Published: 6 November 2023
... resistance and adipose tissue inflammation (ATM), characterized by macrophage infiltration into adipose cells. This study presents a new Drosophila model to investigate the mechanisms underlying these obesity-related pathologies. We employed genetic manipulation to reduce ecdysone levels to prolong...
View article titled, A <span class="search-highlight">Drosophila</span> <span class="search-highlight">model</span> targets Eiger&#x2F;TNFα to alleviate obesity-related insulin resistance and macrophage infiltration
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Includes: Supplementary data
Journal Articles

Impaired muscle morphology in a Drosophila model of myosin storage myopathy was suppressed by overexpression of an E3 ubiquitin ligase

In collection:
Drosophila as a Disease Model , Neuromuscular Disease
Martin Dahl-Halvarsson, Montse Olive, Malgorzata Pokrzywa, Michaela Norum, Katarina Ejeskär, Homa Tajsharghi
Journal: Disease Models & Mechanisms
Dis Model Mech (2020) 13 (12): dmm047886.
https://doi.org/10.1242/dmm.047886
Published: 29 December 2020
... cardiomyopathy, as well as skeletal muscle disease. A dominant missense mutation (R1845W) in MYH7 has been reported in several unrelated cases of myosin storage myopathy. We have developed a Drosophila model for a myosin storage myopathy in order to investigate the dose-dependent mechanisms underlying...
View article titled, Impaired muscle morphology in a <span class="search-highlight">Drosophila</span> <span class="search-highlight">model</span> of myosin storage myopathy was suppressed by overexpression of an E3 ubiquitin ligase
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Journal Articles

Feeding difficulties, a key feature of the Drosophila NDUFS4 mitochondrial disease model

In collection:
Drosophila as a Disease Model
Sarah Foriel, Julien Beyrath, Ilse Eidhof, Richard J. Rodenburg, Annette Schenck, Jan A. M. Smeitink
Journal: Disease Models & Mechanisms
Dis Model Mech (2018) 11 (3): dmm032482.
https://doi.org/10.1242/dmm.032482
Published: 27 March 2018
... the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: The characterization of a novel Drosophila model...
View article titled, Feeding difficulties, a key feature of the Drosophila NDUFS4 mitochondrial disease model
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Includes: Supplementary data
Journal Articles

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer’s disease

Ko-Fan Chen, Bernard Possidente, David A. Lomas, Damian C. Crowther
Journal: Disease Models & Mechanisms
Dis Model Mech (2014) 7 (4): 445–458.
https://doi.org/10.1242/dmm.014134
Published: 1 April 2014
... . Crowther   D. C. , Kinghorn   K. J. , Miranda   E. , Page   R. , Curry   J. A. , Duthie   F. A. I. , Gubb   D. C. , Lomas   D. A. ( 2005 ). Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer’s disease . Neuroscience   132 , 123...
View article titled, The central molecular clock is robust in the face of behavioural arrhythmia in a <span class="search-highlight">Drosophila</span> <span class="search-highlight">model</span> of Alzheimer’s disease
Open the PDF for The central molecular clock is robust in the face of behavioural arrhythmia in a <span class="search-highlight">Drosophila</span> <span class="search-highlight">model</span> of Alzheimer’s disease in another window
Includes: Supplementary data