... identified a genetic locus (near ATP5G1 , UBE2Z , SNF8 , IGF2BP1 and GIP ) linked to insomnia and CVD. We used Drosophila models to perform tissue-specific RNA interference knockdowns of four conserved orthologs ( ATPsynC , lsn , Bruce and Imp ) in neurons and the heart. Neuronal-specific knockdown...

... resistance and adipose tissue inflammation (ATM), characterized by macrophage infiltration into adipose cells. This study presents a new Drosophila model to investigate the mechanisms underlying these obesity-related pathologies. We employed genetic manipulation to reduce ecdysone levels to prolong...

... cardiomyopathy, as well as skeletal muscle disease. A dominant missense mutation (R1845W) in MYH7 has been reported in several unrelated cases of myosin storage myopathy. We have developed a Drosophila model for a myosin storage myopathy in order to investigate the dose-dependent mechanisms underlying...

... Drosophila model of NDUFS4 mitochondrial disease revealed a pronounced defect in feeding abilities and recapitulated additional human disease features. Disease model Drosophila model Feeding impairment Mitochondrial disease Among the five complexes forming the mitochondrial oxidative...

... that the original work is properly attributed. Alzheimer’s disease Circadian dysfunction Non-cell-autonomous Aβ toxicity Drosophila model Biological clock Alzheimer’s disease (AD) is the most common cause of dementia in adults and is characterised at the microscopic level by extracellular...