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Keywords: Drosophila
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Journal Articles
Dis Model Mech (2022) 15 (6): dmm049447.
Published: 28 June 2022
... whether known neurotoxic modifiers can suppress circadian dysfunction. We performed a screen of neurotoxicity-modifier genes to suppress circadian behavioural arrhythmicity in a Drosophila circadian HD model. The molecular chaperones Hsp40 and HSP70 emerged as significant suppressors in the circadian...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (5): dmm049218.
Published: 9 May 2022
... certain disadvantages in that obtaining results is time-consuming, owing to relatively long lifespans, and these results have low statistical resolution because sample sizes are usually small. Here, we report a targeted genetic screening of 5698 RNAi lines encompassing 4135 Drosophila genes with human...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
Dis Model Mech (2022) 15 (5): dmm049551.
Published: 9 May 2022
... how changes in host metabolism contribute to host defence. Using Drosophila as a model system, we identify induction of intestinal target-of-rapamycin (TOR) kinase signalling as a key adaptive metabolic response to enteric infection. We find that enteric infection induces both local and systemic...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (4): dmm049184.
Published: 3 May 2022
... (officially known as Thor in Drosophila and EIF4EBP2 in humans), an ATF4 transcriptional target. Lastly, mutations in human PrP (N159D, D167S, N174S) showed partial protective activity, revealing its high propensity to misfold into toxic conformations. 26 6 2021 1 2 2022 © 2022. Published...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (3): dmm049332.
Published: 28 March 2022
... by producing local and systemic signals that are relayed to the body and that maintain intestinal and organismal homeostasis. Consequently, disruption of intestinal homeostasis and signalling are associated with systemic diseases and multi-organ dysfunction. In recent years, the fruit fly Drosophila...
Journal Articles
Dis Model Mech (2022) 15 (3): dmm049513.
Published: 28 March 2022
... to replicate in animal models and are, in part, responsible for the failures in translational cancer research. In this Perspective, we highlight the fruit fly, Drosophila melanogaster , as a powerful model organism to investigate multimorbidity and tumour diversity. We also highlight how harnessing...
Journal Articles
Dis Model Mech (2022) 15 (3): dmm049298.
Published: 23 March 2022
... of cachexia, our understanding of how tumors interact with host tissues and how they affect metabolism is limited. Among the challenges of studying tumor–host tissue crosstalk are the complexity of cancer itself and our insufficient knowledge of the factors that tumors release into the blood. Drosophila...
Journal Articles
In collection:
The RAS Pathway
Dis Model Mech (2022) 15 (2): dmm048953.
Published: 19 November 2021
...Jun-yi Zhu; Xiaohu Huang; Yulong Fu; Yin Wang; Pan Zheng; Yang Liu; Zhe Han ABSTRACT Oncogenic Ras mutations are highly prevalent in hematopoietic malignancies. However, it is difficult to directly target oncogenic RAS proteins for therapeutic intervention. We have developed a Drosophila acute...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (9): dmm047464.
Published: 21 September 2021
... proteostasis network extends lifespan and prevents age-related diseases. However, how proteostasis is regulated in different tissues throughout the aging process remains unclear. Here, we show that Drosophila homologs of Cubilin- and Amnionless (dCubilin and dAMN, respectively)-mediated protein reabsorption...
Journal Articles
Dis Model Mech (2021) 14 (8): dmm048931.
Published: 31 August 2021
... plays an essential role in the production of mature tRNAs. To establish a causal connection between ELAC2 variants and CM, here we used the Drosophila melanogaster model organism, which carries the ELAC2 homolog RNaseZ. Even though RNaseZ and ELAC2 have diverged in some of their biological functions...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (7): dmm048603.
Published: 12 July 2021
... of clinical outcomes and design of personalized treatment options. The power of a genetically tractable model organism coupled with well-established in vivo assays and a relatively short life cycle make Drosophila an attractive system to study VCP disease pathogenesis. Using CRISPR/Cas9, we have generated...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (6): dmm047811.
Published: 14 June 2021
... and cognitive impairments. Similar phenotypes can be induced in Drosophila melanogaster through modification of PD-relevant genes or the administration of PD-inducing toxins. Recent studies correlated deregulation of human p21-activated kinase 4 (PAK4) with PD, leaving open the question of a causative...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (1): dmm046417.
Published: 22 January 2021
... secretory cells, which synthesize and secrete massive quantities of cargo proteins via regulated exocytosis. The Drosophila larval salivary glands are composed of professional secretory cells that synthesize and secrete mucin proteins at the onset of metamorphosis. Using the larval salivary glands...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (8): dmm044750.
Published: 27 August 2020
... developed a Drosophila model of MSUD by knocking out the dDBT gene, an ortholog of the human gene encoding the dihydrolipoamide branched chain transacylase (DBT) subunit of BCKDH. The homozygous dDBT mutant larvae recapitulate an array of MSUD phenotypes, including aberrant BCAA accumulation, developmental...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (7): dmm044420.
Published: 23 July 2020
..., specifically their TONDU domain, competitively inhibit YAP-TEAD interaction, resulting in arrest of tumor growth. Here, we show that overexpression of the TONDU peptide or its oral uptake leads to suppression of Yki-driven intestinal stem cell tumors in the adult Drosophila midgut. In addition, comparative...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (7): dmm044883.
Published: 22 July 2020
... during embryonic and fetal stages and reflect stereotypical changes in the proliferative properties of neural progenitors. The temporal mechanisms underlying these proliferation patterns are still unclear in mammals. In Drosophila , two decades of work have revealed a network of sequentially expressed...
Journal Articles
Dis Model Mech (2020) 13 (6): dmm043174.
Published: 26 June 2020
... contexts remain largely unknown. Here, we establish a Drosophila melanogaster model for RP13 by introducing the nine distinct RP mutations into the fly PRPF8 ortholog prp8 and express the mutant proteins in precise spatiotemporal patterns using the Gal4/UAS system. We show that all nine RP-Prp8 mutant...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (4): dmm040816.
Published: 30 April 2020
...Sneh Harsh; Yulong Fu; Eric Kenney; Zhe Han; Ioannis Eleftherianos ABSTRACT To gain a comprehensive view of the changes in host gene expression underlying Zika virus (ZIKV) pathogenesis, we performed whole-genome RNA sequencing (RNA-seq) of ZIKV-infected Drosophila adult flies. RNA-seq analysis...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (6): dmm037721.
Published: 18 June 2019
...Mayo Araki; Massanori Kurihara; Suzuko Kinoshita; Rie Awane; Tetsuya Sato; Yasuyuki Ohkawa; Yoshihiro H. Inoue ABSTRACT The innate immune response is the first line of defence against microbial infections. In Drosophila , two major pathways of the innate immune system (the Toll- and Imd-mediated...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (5): dmm038679.
Published: 30 May 2019
... V617F ), which encodes a dominant-active kinase that constitutively triggers JAK/STAT signaling. In Drosophila , this pathway is simplified, with a single JAK, Hopscotch (Hop), and a single STAT transcription factor, Stat92E. The hop Tumorous-lethal [ hop Tum ] allele encodes a dominant-active kinase...
Includes: Supplementary data