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Keywords: Drosophila
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Journal Articles
Dis Model Mech (2021) 14 (1): dmm046417.
Published: 22 January 2021
... secretory cells, which synthesize and secrete massive quantities of cargo proteins via regulated exocytosis. The Drosophila larval salivary glands are composed of professional secretory cells that synthesize and secrete mucin proteins at the onset of metamorphosis. Using the larval salivary glands as a...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (8): dmm044750.
Published: 27 August 2020
... developed a Drosophila model of MSUD by knocking out the dDBT gene, an ortholog of the human gene encoding the dihydrolipoamide branched chain transacylase (DBT) subunit of BCKDH. The homozygous dDBT mutant larvae recapitulate an array of MSUD phenotypes, including aberrant BCAA accumulation, developmental...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (7): dmm044420.
Published: 23 July 2020
..., specifically their TONDU domain, competitively inhibit YAP-TEAD interaction, resulting in arrest of tumor growth. Here, we show that overexpression of the TONDU peptide or its oral uptake leads to suppression of Yki-driven intestinal stem cell tumors in the adult Drosophila midgut. In addition, comparative...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (7): dmm044883.
Published: 22 July 2020
... during embryonic and fetal stages and reflect stereotypical changes in the proliferative properties of neural progenitors. The temporal mechanisms underlying these proliferation patterns are still unclear in mammals. In Drosophila , two decades of work have revealed a network of sequentially expressed...
Journal Articles
Dis Model Mech (2020) 13 (6): dmm043174.
Published: 26 June 2020
... contexts remain largely unknown. Here, we establish a Drosophila melanogaster model for RP13 by introducing the nine distinct RP mutations into the fly PRPF8 ortholog prp8 and express the mutant proteins in precise spatiotemporal patterns using the Gal4/UAS system. We show that all nine RP-Prp8 mutant...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (4): dmm040816.
Published: 30 April 2020
...Sneh Harsh; Yulong Fu; Eric Kenney; Zhe Han; Ioannis Eleftherianos ABSTRACT To gain a comprehensive view of the changes in host gene expression underlying Zika virus (ZIKV) pathogenesis, we performed whole-genome RNA sequencing (RNA-seq) of ZIKV-infected Drosophila adult flies. RNA-seq analysis...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (6): dmm037721.
Published: 18 June 2019
...Mayo Araki; Massanori Kurihara; Suzuko Kinoshita; Rie Awane; Tetsuya Sato; Yasuyuki Ohkawa; Yoshihiro H. Inoue ABSTRACT The innate immune response is the first line of defence against microbial infections. In Drosophila , two major pathways of the innate immune system (the Toll- and Imd-mediated...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (5): dmm038679.
Published: 30 May 2019
... V617F ), which encodes a dominant-active kinase that constitutively triggers JAK/STAT signaling. In Drosophila , this pathway is simplified, with a single JAK, Hopscotch (Hop), and a single STAT transcription factor, Stat92E. The hop Tumorous-lethal [ hop Tum ] allele encodes a dominant-active kinase...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (5): dmm039180.
Published: 13 May 2019
... methodologies, the fruit fly Drosophila melanogaster is ideally positioned to change gear in ID and ASD research. The aim of this Review is to summarize some of the exciting work that already has drawn attention to Drosophila as a model for these disorders. We highlight well-established ID- and ASD-relevant fly...
Journal Articles
Dis Model Mech (2019) 12 (4): dmm039032.
Published: 01 April 2019
...Santiago Nahuel Villegas ABSTRACT When Mary Stark first described the presence of tumours in the fruit fly Drosophila melanogaster in 1918, would she ever have imagined that flies would become an invaluable organism for modelling and understanding oncogenesis? And if so, would she have expected it...
Journal Articles
Dis Model Mech (2018) 11 (12): dmm034520.
Published: 28 November 2018
... complementary model systems to examine the effects of food additives on gut barrier function: a Drosophila in vivo model and an in vitro human cell co-culture model. Of the additives tested, intestinal permeability was increased most dramatically by high sugar. High sugar also increased feeding but reduced gut...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (7): dmm033811.
Published: 20 July 2018
... progressive neurodegeneration and cardiomyopathy, the latter being the most common cause of death in patients. We previously developed a Drosophila melanogaster cardiac model of FA, in which the fly frataxin is inactivated specifically in the heart, leading to heart dilatation and impaired systolic function...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (6): dmm031492.
Published: 31 May 2018
...Tongchao Li; Hugo J. Bellen; Andrew K. Groves ABSTRACT Johnston's organ – the hearing organ of Drosophila – has a very different structure and morphology to that of the hearing organs of vertebrates. Nevertheless, it is becoming clear that vertebrate and invertebrate auditory organs share many...
Journal Articles
Dis Model Mech (2018) 11 (5): dmm031849.
Published: 21 May 2018
... factors, MBNL1 and CELF1. The contribution of CELF1 to DM1 phenotypes is controversial. Here, we show that the Drosophila CELF1 family member, Bru - 3, contributes to pathogenic muscle defects observed in a Drosophila model of DM1. Bru-3 displays predominantly cytoplasmic expression in muscles and its...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (5): dmm034231.
Published: 10 May 2018
... signaling in diabetes-associated hypersensitivity remains obscure. Here, we used Drosophila nociception/nociceptive sensitization assays to investigate the role of Insulin receptor (Insulin-like receptor, InR) in nociceptive hypersensitivity. InR mutant larvae exhibited mostly normal baseline thermal...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (4): dmm032557.
Published: 23 April 2018
... dysfunction is unclear. We overexpressed Muscleblind ( Mbl ), the Drosophila MBNL orthologue, in cardiomyocytes of DM1 model flies and observed a rescue of heart dysfunctions, which are characteristic of these model flies and resemble cardiac defects observed in patients. We also identified a drug...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (3): dmm031161.
Published: 08 March 2018
... chronological age. Here, we develop a comprehensive metric for physiological age in Drosophila , based on genome-wide expression profiling. We applied this metric to a model of adult-onset neurodegeneration, increased or decreased expression of the activating subunit of the Cdk5 protein kinase, encoded by the...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (1): dmm029082.
Published: 17 January 2018
... in the human JPH2 gene are associated with hypertrophic and dilated cardiomyopathies; mutations in JPH3 are responsible for the neurodegenerative Huntington's disease-like-2 (HDL2), whereas JPH1 acts as a genetic modifier in Charcot–Marie–Tooth 2K peripheral neuropathy. Drosophila melanogaster has a...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (12): 1453–1464.
Published: 01 December 2017
...Zachary Fischer; Rahul Das; Anna Shipman; Jin-Yuan Fan; Laramie Pence; Samuel Bouyain; Leonard L. Dobens ABSTRACT Members of the Tribbles family of proteins are conserved pseudokinases with diverse roles in cell growth and proliferation. Both Drosophila Tribbles (Trbl) and vertebrate Trib3 proteins...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (12): 1381–1389.
Published: 01 December 2017
... original work is properly attributed. Summary: Curiosity-driven research using simple organisms has and will continue to lead to fundamental discoveries about biology that are directly applicable to improving the human condition. C. elegans Drosophila Invertebrates Sea urchin Yeast...