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Keywords: Diabetes
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Journal Articles
Dis Model Mech (2021) 14 (4): dmm048909.
Published: 15 April 2021
...Sarah E. Elzinga; Masha G. Savelieff; Phillipe D. O'Brien; Faye E. Mendelson; John M. Hayes; Eva L. Feldman ABSTRACT Peripheral neuropathy (PN) is a common complication of prediabetes and diabetes and is an increasing problem worldwide. Existing PN treatments rely solely on glycemic control, which...
Journal Articles
Dis Model Mech (2019) 12 (9): dmm039867.
Published: 25 September 2019
...Karishma Chhabria; Avgoustinos Vouros; Caroline Gray; Ryan B. MacDonald; Zhen Jiang; Robert Neil Wilkinson; Karen Plant; Eleni Vasilaki; Clare Howarth; Timothy J. A. Chico ABSTRACT Diabetes is associated with dysfunction of the neurovascular unit, although the mechanisms of this are incompletely...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (1): dmm036004.
Published: 23 January 2019
...Luis Fernando Delgadillo-Silva; Anastasia Tsakmaki; Nadeem Akhtar; Zara J. Franklin; Judith Konantz; Gavin A. Bewick; Nikolay Ninov ABSTRACT Islet inflammation and cytokine production are implicated in pancreatic β-cell dysfunction and diabetes pathogenesis. However, we lack therapeutics to protect...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (12): dmm036012.
Published: 18 December 2018
... catabolism in IVD degeneration remains an important clinical challenge. Pro-oxidant and structure-modifying advanced glycation end-products (AGEs) contribute to obesity and diabetes, which are associated with increased back pain, and accumulate in tissues due to hyperglycemia or ingestion of foods processed...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (10): dmm035220.
Published: 22 October 2018
... to specific cone types, indicating the rapid onset of neural complications in the zebrafish model of diabetic retinopathy. * Author for correspondence ( vconn@american.edu ) Competing interests The authors declare no competing or financial interests. 24 4 2018 22 8 2018...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (5): dmm034231.
Published: 10 May 2018
...Seol Hee Im; Atit A. Patel; Daniel N. Cox; Michael J. Galko ABSTRACT Diabetes-associated nociceptive hypersensitivity affects diabetic patients with hard-to-treat chronic pain. Because multiple tissues are affected by systemic alterations in insulin signaling, the functional locus of insulin...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (10): 1217–1227.
Published: 01 October 2017
...Yanyi Sun; Qiuyun Wang; Yuehua Fang; Chunfang Wu; Guoping Lu; Zhenyue Chen ABSTRACT Hyperglycemia is an independent risk factor for diabetic cardiomyopathy in humans; however, the underlying mechanisms have not been thoroughly elucidated. Zebrafish ( Danio rerio ) was used in this study as a novel...
Includes: Supplementary data
Journal Articles
In collection:
Metabolic Disorders
Dis Model Mech (2016) 9 (5): 573–583.
Published: 01 May 2016
...Eva Baquedano; Emma Burgos-Ramos; Sandra Canelles; Agueda González-Rodríguez; Julie A. Chowen; Jesús Argente; Vicente Barrios; Angela M. Valverde; Laura M. Frago ABSTRACT Insulin receptor substrate-2-deficient ( IRS2 −/− ) mice are considered a good model to study the development of diabetes...
Journal Articles
Dis Model Mech (2016) 9 (4): 365–376.
Published: 01 April 2016
... storage and utilization. Defects in these pathways lead to phenotypes that are analogous to diabetic states in mammals. These discoveries have stimulated interest in leveraging the fly to better understand the genetics of type 2 diabetes mellitus in humans. Type 2 diabetes results from insulin...
Journal Articles
Dis Model Mech (2015) 8 (12): 1625–1633.
Published: 01 December 2015
... clinical trials to treat type 1 (T1D) and type 2 diabetes (T2D). However, the therapeutic basis remains to be fully understood. The immunomodulatory property of uMSCs could explain the use in treating T1D; however, the mere immune modulation might not be sufficient to support the use in T2D. We thus tested...
Journal Articles
Dis Model Mech (2015) 8 (2): 157–168.
Published: 01 February 2015
...Beatriz López-Escobar; David A. Cano; Anabel Rojas; Beatriz de Felipe; Francisco Palma; José A. Sánchez-Alcázar; Deborah Henderson; Patricia Ybot-González Embryopathies that develop as a consequence of maternal diabetes have been studied intensely in both experimental and clinical scenarios...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (1): 65–80.
Published: 01 January 2015
...Milad S. Bitar; Fahd Al-Mulla Impaired angiogenesis and endothelial dysfunction in type 2 diabetes constitute dominant risk factors for non-healing wounds and most forms of cardiovascular disease. We propose that diabetes shifts the ‘angiogenic balance’ in favor of an excessive anti-angiogenic...
Journal Articles
Dis Model Mech (2014) 7 (12): 1341–1350.
Published: 01 December 2014
... Mineralization Obesity Diabetes Bone remodelling is a highly conserved and regulated process that controls bone homeostasis and maintains skeletal structural integrity. This vital function is characterized by alternating phases of bone resorption by osteoclasts and bone formation by osteoblasts, and...
Journal Articles
Dis Model Mech (2014) 7 (6): 723–730.
Published: 01 June 2014
...Cheng Chen; Yun Wang; Juan Zhang; Lian Ma; Jiang Gu; Guyu Ho Major depression disorder (MDD) or depression is highly prevalent in individuals with diabetes, and the depressive symptoms are more severe and less responsive to antidepressant therapies in these patients. The underlying mechanism is...