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1-4 of 4
Keywords: DYRK1A
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Journal Articles
Sex-specific trisomic Dyrk1a -related skeletal phenotypes during development in a Down syndrome model
Open AccessIn collection:
Developmental Disorders
Jonathan M. LaCombe, Kourtney Sloan, Jared R. Thomas, Matthew P. Blackwell, Isabella Crawford, Flannery Bishop, Joseph M. Wallace, Randall J. Roper
Journal:
Disease Models & Mechanisms
Dis Model Mech (2024) 17 (9): dmm050914.
Published: 23 September 2024
..., but trabecular deficits and Dyrk1a overexpression were transitory until postnatal day (P) 30, when there were persistent trabecular and cortical deficits and Dyrk1a was trending toward overexpression. Correction of DS-related skeletal deficits by a purported DYRK1A inhibitor or through genetic means beginning...
Includes: Supplementary data
Journal Articles
Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish
Open AccessIn collection:
Zebrafish as a Disease Model
Hyun-Ju Cho, Jae-Geun Lee, Jong-Hwan Kim, Seon-Young Kim, Yang Hoon Huh, Hyo-Jeong Kim, Kyu-Sun Lee, Kweon Yu, Jeong-Soo Lee
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (5): dmm037044.
Published: 23 May 2019
...Hyun-Ju Cho; Jae-Geun Lee; Jong-Hwan Kim; Seon-Young Kim; Yang Hoon Huh; Hyo-Jeong Kim; Kyu-Sun Lee; Kweon Yu; Jeong-Soo Lee ABSTRACT DYRK1A is a major causative gene in Down syndrome (DS). Reduced incidence of solid tumors such as neuroblastoma in DS patients and increased vascular anomalies in DS...
Includes: Supplementary data
Journal Articles
Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A
Open AccessIn collection:
Neurodegenerative Disorders
Thu Lan Nguyen, Arnaud Duchon, Antigoni Manousopoulou, Nadège Loaëc, Benoît Villiers, Guillaume Pani, Meltem Karatas, Anna E. Mechling, Laura-Adela Harsan, Emmanuelle Limanton, Jean-Pierre Bazureau, François Carreaux, Spiros D. Garbis, Laurent Meijer, Yann Herault
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (9): dmm035634.
Published: 27 September 2018
... the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate that pharmacological inhibition of brain DYRK1A is able to correct recognition memory deficits in three DS mouse models with increasing genetic complexity [Tg( Dyrk1a...
Includes: Supplementary data
Journal Articles
A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition
Open AccessHyeongki Kim, Kyu-Sun Lee, Ae-Kyeong Kim, Miri Choi, Kwangman Choi, Mingu Kang, Seung-Wook Chi, Min-Sung Lee, Jeong-Soo Lee, So-Young Lee, Woo-Joo Song, Kweon Yu, Sungchan Cho
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (8): 839–848.
Published: 1 August 2016
...Hyeongki Kim; Kyu-Sun Lee; Ae-Kyeong Kim; Miri Choi; Kwangman Choi; Mingu Kang; Seung-Wook Chi; Min-Sung Lee; Jeong-Soo Lee; So-Young Lee; Woo-Joo Song; Kweon Yu; Sungchan Cho ABSTRACT DYRK1A is important in neuronal development and function, and its excessive activity is considered a significant...
Includes: Supplementary data
