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Keywords: DPRs
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Journal Articles
Fréderike W. Riemslagh, Esmay C. van der Toorn, Rob F. M. Verhagen, Alex Maas, Laurens W. J. Bosman, Renate K. Hukema, Rob Willemsen
Journal:
Disease Models & Mechanisms
Dis Model Mech (2021) 14 (2): dmm044842.
Published: 16 February 2021
...) and amyotrophic lateral sclerosis (ALS) cases. Numerous studies have indicated the toxicity of dipeptide repeats (DPRs), which are produced via repeat-associated non-AUG (RAN) translation from the repeat expansion, and accumulate in the brain of C9FTD/ALS patients. Mouse models expressing the human C9ORF72 repeat...
Includes: Supplementary data
