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1-4 of 4
Keywords: DNA repair
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Journal Articles
In collection:
Cancer Metabolism
Journal:
Disease Models & Mechanisms
Dis Model Mech (2024) 17 (8): dmm050775.
Published: 29 August 2024
... the causes and consequences of dNTP pool perturbations in cancer cells, together with their impact upon genome stability. Deoxynucleoside triphosphate (dNTP) metabolism Genome stability DNA repair Cancer Vetenskapsrådet http://dx.doi.org/10.13039/501100004359 2018-02114...
Journal Articles
Nicolas G. Clavere, Ali Alqallaf, Kerry A. Rostron, Andrew Parnell, Robert Mitchell, Ketan Patel, Samuel Y. Boateng
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (5): dmm049424.
Published: 9 May 2022
... and skeletal muscle, resulting in both morphological and changes in gene expression ( Lodberg, 2021 ). In conclusion, we have shown for the first time that a model of attenuated DNA repair is associated with pathological cardiac remodelling and gene expression. However, a significant amount...
Includes: Supplementary data
Journal Articles
In collection:
Neurodegenerative Disorders
Georgina Askeland, Marie Rodinova, Hana Štufková, Zaneta Dosoudilova, Monika Baxa, Petra Smatlikova, Bozena Bohuslavova, Jiri Klempir, The Duong Nguyen, Anna Kuśnierczyk, Magnar Bjørås, Arne Klungland, Hana Hansikova, Zdenka Ellederova, Lars Eide
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (10): dmm035949.
Published: 24 October 2018
..., oxidative stress, DNA integrity and DNA repair at different ages (24, 36 and 48 months), and compared with age-matched controls. The TgHD minipigs showed progressive accumulation of the mutant huntingtin (mHTT) fragment in brain tissue and exhibited locomotor functional decline at 48 months. Interestingly...
Includes: Supplementary data
Journal Articles
In collection:
Neurodegenerative Disorders
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (1): dmm031930.
Published: 30 January 2018
... and central neurodegeneration, but our understanding of how expanded repeats drive neuronal loss is incomplete. Recent human genetic evidence implicates DNA repair pathways, especially mismatch repair, in modifying the onset and progression of CAG repeat diseases. Repair pathways might operate directly...