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Keywords: DNA methylation
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Journal Articles

Effects of alcohol on the transcriptome, methylome and metabolome of in vitro gastrulating human embryonic cells

Open Access
E. Wallén, K. Rämö, J. Vehviläinen, J. Sokka, M. Lehtonen, T. Otonkoski, R. Trokovic, P. Auvinen, O. Kärkkäinen, N. Kaminen-Ahola
Journal: Disease Models & Mechanisms
Dis Model Mech (2025) 18 (6): dmm052150.
https://doi.org/10.1242/dmm.052150
Published: 18 June 2025
...), DNA methylation (EPIC Illumina microarrays) and metabolome (non-targeted LC-MS) of the endodermal, mesodermal and ectodermal cells. The largest number of ethanol-induced alterations were observed in endodermal cells, whereas the most prominent changes were in ectodermal cells. Methionine metabolism...
View article titled, Effects of alcohol on the transcriptome, methylome and metabolome of in vitro gastrulating human embryonic cells
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Includes: Supplementary data
Journal Articles

Glucocorticoid receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain

Open Access
In collection:
Zebrafish as a Disease Model
Helen Eachus, Lara Oberski, Jack Paveley, Irina Bacila, John-Paul Ashton, Umberto Esposito, Fayaz Seifuddin, Mehdi Pirooznia, Eran Elhaik, Marysia Placzek, Nils P. Krone, Vincent T. Cunliffe
Journal: Disease Models & Mechanisms
Dis Model Mech (2023) 16 (9): dmm050141.
https://doi.org/10.1242/dmm.050141
Published: 2 October 2023
... to cognition . Physiol. Rev. 94 , 991 - 1026 . 10.1152/physrev.00004.2014 Anastasiadi , D. , Esteve-Codina , A. and Piferrer , F. (2018). Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species . Epigenet...
View article titled, Glucocorticoid receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain
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Includes: Supplementary data
Journal Articles

Identification of early indicators of altered metabolism in normal development using a rodent model system

Open Access
In collection:
Rat as a Disease Model
Ashok Daniel Prabakaran, Jimsheena Valiyakath Karakkat, Ranjit Vijayan, Jisha Chalissery, Marwa F. Ibrahim, Suneesh Kaimala, Ernest A. Adeghate, Ahmed Hassan Al-Marzouqi, Suraiya Anjum Ansari, Eric Mensah-Brown, Bright Starling Emerald
Journal: Disease Models & Mechanisms
Dis Model Mech (2018) 11 (3): dmm031815.
https://doi.org/10.1242/dmm.031815
Published: 1 March 2018
... and Pparγ signaling Expression array DNA methylation Dnmt1 repressor complex Evidence from a wide variety of molecular, epidemiological and meta-analytical studies has linked the quality of later adult life to the early maternal developmental environment, and showed that variations in them...
View article titled, Identification of early indicators of altered metabolism in normal development using a rodent model system
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Includes: Supplementary data