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Keywords: DNA damage
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Journal Articles
Journal:
Disease Models & Mechanisms
Dis Model Mech (2021) 14 (5): dmm048793.
Published: 10 May 2021
... phenomena drive DNA damage, chromosomal instability, stress response signaling, altered gene expression, epigenetic modification and cellular proliferation in bystander cells. Myeloid-derived cells are important effectors in both phenomena. A better understanding of the interactions between the gut...
Journal Articles
Giusj Monia Pugliese, Federico Salaris, Valentina Palermo, Veronica Marabitti, Nicolò Morina, Alessandro Rosa, Annapaola Franchitto, Pietro Pichierri
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (10): dmm039487.
Published: 17 October 2019
... iPSCs induces replication-dependent and chronic accumulation of DNA damage triggering the DNA damage response. Furthermore, they indicate that accumulation of DNA damage and activation of the DNA damage response correlates with increased levels of R-loops and replication-transcription interference...
Includes: Supplementary data
Journal Articles
In collection:
Neurodegenerative Disorders
Georgina Askeland, Marie Rodinova, Hana Štufková, Zaneta Dosoudilova, Monika Baxa, Petra Smatlikova, Bozena Bohuslavova, Jiri Klempir, The Duong Nguyen, Anna Kuśnierczyk, Magnar Bjørås, Arne Klungland, Hana Hansikova, Zdenka Ellederova, Lars Eide
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (10): dmm035949.
Published: 24 October 2018
... DNA damage DNA repair HD large animal model Norges Forskningsråd MSMT-28477/2014 Ministerstvo Školství, Mládeže a Tělovýchovy COST LD15099 LO1609 Univerzita Karlova v Praze 10.13039/100007397 PROGRES Q26/LF1/3 Helse Midt-Norge 10.13039/501100004590...
Includes: Supplementary data
Journal Articles
In collection:
Neurodegenerative Disorders
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (1): dmm031930.
Published: 30 January 2018
... on repeat sequences by licensing or inhibiting repeat expansion in neurons. Alternatively, or in addition, because many of the genes containing pathogenic CAG repeats encode proteins that themselves have roles in the DNA damage response, it is possible that repeat expansions impair specific DNA repair...