... significantly reduced in Il33 −/− diabetic mice compared with those in wild-type counterparts. The Il33 −/− diabetic retina also exhibited microglial activation, sustained gliosis, and upregulation of pro-inflammatory cytokines and neurotrophins. Primary Müller cells from Il33 −/− mice expressed significantly...

...Sara Ibrahim; Arianna Harris-Kawano; Isra Haider; Raghavendra G. Mirmira; Emily K. Sims; Ryan M. Anderson ABSTRACT Maladaptive signaling by pro-inflammatory cytokines (PICs), such as TNFα, IL1β and IFNɣ, can activate downstream signaling cascades that are implicated in the development...

.... Although the complex local and disseminating pathological processes of a burn injury ultimately stem from local tissue damage, to date relatively few studies have attempted to characterise the local inflammatory mediator profile. Here, cytokine content and associated transcriptional changes were measured...

... to as CMO/MC – ) showed a significant delay in disease onset compared with age-matched CMO mice. At 5-6 months of age, CMO/MC – mice had fewer bone lesions and immune infiltration in the popliteal lymph nodes that drain the affected tissues. In bone marrow-derived mast cell cultures from CMO mice, cytokine...

... of acute inflammation as a result of impaired secretion of proinflammatory cytokines by macrophages. To investigate the impaired cytokine secretion and confirm our previous findings, we performed transcriptomic analysis in macrophages and identified a subgroup of individuals with CD who had low expression...