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Keywords: Cytokines
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Journal Articles
Dis Model Mech (2020) 13 (6): dmm042556.
Published: 26 June 2020
...Sara Ibrahim; Arianna Harris-Kawano; Isra Haider; Raghavendra G. Mirmira; Emily K. Sims; Ryan M. Anderson ABSTRACT Maladaptive signaling by pro-inflammatory cytokines (PICs), such as TNFα, IL1β and IFNɣ, can activate downstream signaling cascades that are implicated in the development and...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (4): dmm042713.
Published: 29 April 2020
.... Although the complex local and disseminating pathological processes of a burn injury ultimately stem from local tissue damage, to date relatively few studies have attempted to characterise the local inflammatory mediator profile. Here, cytokine content and associated transcriptional changes were measured...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (8): dmm040097.
Published: 20 August 2019
..., cytokine production in response to the alarmin IL-33 was elevated compared with wild-type cultures. To test the relevance of mast cells to human CRMO, we tested serum samples from a cohort of healthy controls and from CRMO patients at diagnosis. Interestingly, mast cell chymase was elevated in CRMO...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (8): 817–829.
Published: 01 August 2015
... of acute inflammation as a result of impaired secretion of proinflammatory cytokines by macrophages. To investigate the impaired cytokine secretion and confirm our previous findings, we performed transcriptomic analysis in macrophages and identified a subgroup of individuals with CD who had low...
Includes: Supplementary data