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Keywords: Cyclophilin D
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Journal Articles
Nadia Sachewsky, Jessica Hunt, Michael J. Cooke, Ashkan Azimi, Taraneh Zarin, Carween Miu, Molly S. Shoichet, Cindi M. Morshead
Journal:
Disease Models & Mechanisms
Dis Model Mech (2014) 7 (8): 953–961.
Published: 1 August 2014
... a calcineurin-independent pathway mediated by CsA binding to cyclophilin D in mitochondria. We have established that NIM811 (which binds with cyclophilin D) but not FK506 (which inhibits calcineurin) has a direct effect on adult NPCs, similar to CsA. Specifically, CsA and NIM811 increase the numbers and size...