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Journal Articles

An adherent-invasive Escherichia coli -colonized mouse model to evaluate microbiota-targeting strategies in Crohn's disease

In collection:

Infectious disease biology

Adeline Sivignon, Mélissa Chervy, Caroline Chevarin, Elia Ragot, Elisabeth Billard, Jérémy Denizot, Nicolas Barnich

Dis Model Mech (2022) 15 (10): dmm049707.

https://doi.org/10.1242/dmm.049707

Published: 24 October 2022

...Adeline Sivignon; Mélissa Chervy; Caroline Chevarin; Elia Ragot; Elisabeth Billard; Jérémy Denizot; Nicolas Barnich ABSTRACT Adherent-invasive Escherichia coli (AIEC) were investigated for their involvement in the induction/chronicity of intestinal inflammation in Crohn's disease (CD). AIEC gut...

View article titled, An adherent-invasive Escherichia coli -colonized mouse model to evaluate microbiota-targeting strategies in <span class="search-highlight">Crohn's</span> <span class="search-highlight">disease</span>

Includes: Supplementary data

Journal Articles

Thiopurines correct the effects of autophagy impairment on intestinal healing – a potential role for ARHGAP18/RhoA

Marileen M. C. Prins, Francesca P. Giugliano, Manon van Roest, Stan F. J. van de Graaf, Pim J. Koelink, Manon E. Wildenberg

Dis Model Mech (2021) 14 (4): dmm047233.

https://doi.org/10.1242/dmm.047233

Published: 23 April 2021

...Marileen M. C. Prins; Francesca P. Giugliano; Manon van Roest; Stan F. J. van de Graaf; Pim J. Koelink; Manon E. Wildenberg ABSTRACT The ATG16L1 T300A single-nucleotide polymorphism (SNP) is associated with Crohn's disease and causes an autophagy impairment. We have previously shown that this SNP...

View article titled, Thiopurines correct the effects of autophagy impairment on intestinal healing – a potential role for ARHGAP18/RhoA

Includes: Supplementary data

Journal Articles

Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease

In collection:

Advanced in vitro models , Drug Discovery

Dis Model Mech (2020) 13 (11): dmm044040.

https://doi.org/10.1242/dmm.044040

Published: 27 November 2020

... Macrolide Ulcerative colitis Crohn's disease Seventh Framework Programme 10.13039/100011102 305564 Inflammatory bowel diseases (IBDs) affect 0.5-1.0% of people in the Western world and cause substantial morbidity and cost to society ( Feagan et al., 2014 ; van Deen et al., 2014...

View article titled, Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease

Includes: Supplementary data

Journal Articles

Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease

In collection:

Zebrafish as a Disease Model

Ling-shiang Chuang, Joshua Morrison, Nai-yun Hsu, Philippe Ronel Labrias, Shikha Nayar, Ernie Chen, Nicole Villaverde, Jody Ann Facey, Gilles Boschetti, Mamta Giri, Mireia Castillo-Martin, Tin Htwe Thin, Yashoda Sharma, Jaime Chu, Judy H. Cho

Dis Model Mech (2019) 12 (8): dmm037432.

https://doi.org/10.1242/dmm.037432

Published: 13 August 2019

... determination of time course, cellular contributions and mechanisms of new drugs. Crohn's disease DSS injury model Epithelial barrier IBD Lysosome-rich enterocytes Sanford J. Grossman Trust Crohn's and Colitis Foundation 10.13039/100011684 Gilead Sciences 10.13039...

View article titled, Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease

Includes: Supplementary data

Journal Articles

Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

Thean S. Chew, Nuala R. O'Shea, Gavin W. Sewell, Stefan H. Oehlers, Claire M. Mulvey, Philip S. Crosier, Jasminka Godovac-Zimmermann, Stuart L. Bloom, Andrew M. Smith, Anthony W. Segal

Dis Model Mech (2015) 8 (8): 817–829.

https://doi.org/10.1242/dmm.020362

Published: 1 August 2015

...Thean S. Chew; Nuala R. O'Shea; Gavin W. Sewell; Stefan H. Oehlers; Claire M. Mulvey; Philip S. Crosier; Jasminka Godovac-Zimmermann; Stuart L. Bloom; Andrew M. Smith; Anthony W. Segal ABSTRACT Crohn's disease (CD) is associated with delayed neutrophil recruitment and bacterial clearance at sites...

View article titled, Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

Includes: Supplementary data

NARROW

An adherent-invasive Escherichia coli -colonized mouse model to evaluate microbiota-targeting strategies in Crohn's disease

Thiopurines correct the effects of autophagy impairment on intestinal healing – a potential role for ARHGAP18/RhoA

Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease

Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease

Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

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An adherent-invasive Escherichia coli -colonized mouse model to evaluate microbiota-targeting strategies in Crohn's disease

Thiopurines correct the effects of autophagy impairment on intestinal healing – a potential role for ARHGAP18/RhoA

Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease

Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease

Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

Email alerts

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