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Keywords: Crohn's disease
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Journal Articles
Dis Model Mech (2021) 14 (4): dmm047233.
Published: 23 April 2021
...Marileen M. C. Prins; Francesca P. Giugliano; Manon van Roest; Stan F. J. van de Graaf; Pim J. Koelink; Manon E. Wildenberg ABSTRACT The ATG16L1 T300A single-nucleotide polymorphism (SNP) is associated with Crohn's disease and causes an autophagy impairment. We have previously shown that this SNP...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (11): dmm044040.
Published: 27 November 2020
... bowel diseases NF-κB Drug repositioning Interdisciplinary research Organoids Macrolide Ulcerative colitis Crohn's disease Inflammatory bowel diseases (IBDs) affect 0.5-1.0% of people in the Western world and cause substantial morbidity and cost to society ( Feagan et al., 2014 ; van Deen...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (8): dmm037432.
Published: 13 August 2019
...: Crohn's disease (CD) and ulcerative colitis (UC). While UC affects the superficial layers of the intestine, CD often affects deeper layers of the bowel wall. The most significant loci identified in genome-wide association studies (GWAS) for IBD include protein-altering alleles in IL23R (interleukin 23...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (8): 817–829.
Published: 01 August 2015
...Thean S. Chew; Nuala R. O'Shea; Gavin W. Sewell; Stefan H. Oehlers; Claire M. Mulvey; Philip S. Crosier; Jasminka Godovac-Zimmermann; Stuart L. Bloom; Andrew M. Smith; Anthony W. Segal ABSTRACT Crohn's disease (CD) is associated with delayed neutrophil recruitment and bacterial clearance at sites...
Includes: Supplementary data