... presenting with congenital heart defects and renal hypoplasia, with or without laterality defects. The work presented here enhances our understanding of human development and structure-function relationships in Wnt ligands. Summary: We found a new human WNT11 variant and functionally characterized...

... pharyngeal arch arteries and ventricles, suggesting that these pathways may be relevant to the defects observed. Dysregulation of eNOS leads to embryonic and perinatal death, suggesting mutations in eNOS are candidates for causing congenital heart defects in humans. Surviving eNOS mutants have a deficiency...

... is shown below: (A) a micro-ultrasound snapshot; (B) a 3D projection with segmented organ contours; and (C) a 3D projection. Heart looping is the first morphological sign of left/right asymmetry in the developing embryo and anomalies in this process are associated with congenital heart defects (see...

... and the ductus arteriosus, which connects the aortic arch and pulmonary trunk during fetal development, then closes at birth ( Hiruma et al., 2002 ; Kau et al., 2007 ; Kaufman and Bard, 1999 ; Stewart, 1964 ). Congenital heart defects (CHDs) are the most common structural birth defects in humans...