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Keywords: Collagen
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Journal Articles
Dis Model Mech (2022) 15 (9): dmm049428.
Published: 28 September 2022
...Katie J. Lee; Lisa Rambault; George Bou-Gharios; Peter D. Clegg; Riaz Akhtar; Gabriela Czanner; Rob van ‘t Hof; Elizabeth G. Canty-Laird ABSTRACT The osteogenesis imperfecta murine (oim) model with solely homotrimeric (α1) 3 type I collagen, owing to a dysfunctional α2(I) collagen chain, has...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (9): dmm049175.
Published: 22 September 2021
... mutation causes significant central and peripheral corneal thinning arising from reduced stromal thickness. Expression of key components of the corneal stroma in primary keratocytes from Zfp469 BCS/BCS mice is affected, including decreased Col1a1 and Col1a2 expression. This alters the collagen type I...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (3): dmm048116.
Published: 17 March 2021
...Aikta Sharma; Alice Goring; Peter B. Johnson; Roger J. H. Emery; Eric Hesse; Alan Boyde; Bjorn R. Olsen; Andrew A. Pitsillides; Richard O. C. Oreffo; Sumeet Mahajan; Claire E. Clarkin ABSTRACT Collagen assembly during development is essential for successful matrix mineralisation, which determines...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (12): dmm033654.
Published: 12 December 2018
...Quynh V. Ton; Daniel Leino; Sarah A. Mowery; Nina O. Bredemeier; Pascal J. Lafontant; Allison Lubert; Suman Gurung; Janice L. Farlow; Tatiana M. Foroud; Joseph Broderick; Saulius Sumanas ABSTRACT Collagen XXII (COL22A1) is a quantitatively minor collagen, which belongs to the family of fibril...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (7): dmm034157.
Published: 4 July 2018
...Genki Hayashi; Cassandre Labelle-Dumais; Douglas B. Gould ABSTRACT Collagen type IV alpha 1 (COL4A1) and alpha 2 (COL4A2) form heterotrimers that constitute a major component of nearly all basement membranes. COL4A1 and COL4A2 mutations cause a multisystem disorder that includes variable...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (11): 1301–1312.
Published: 1 November 2017
... of the extracellular matrix [i.e. collagen cross-linking mediated by the lysyl oxidase (LO) family of enzymes (LOX, LOXL1-4)] might contribute to disease pathogenesis and represent a therapeutic target. This study aimed to further our understanding of the mechanisms by which LO inhibitors might improve lung fibrosis...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (6): 751–760.
Published: 1 June 2017
...Li-Fong Seet; Li Zhen Toh; Stephanie W. L. Chu; Sharon N. Finger; Jocelyn L. L. Chua; Tina T. Wong ABSTRACT Excessive accumulation of collagen is often used to assess the development of fibrosis. This study aims to identify collagen genes that define fibrosis in the conjunctiva following glaucoma...
Journal Articles
Dis Model Mech (2015) 8 (12): 1579–1589.
Published: 1 December 2015
...Jennifer L. Philip; Md. Abdur Razzaque; Mei Han; Jinju Li; Tiju Theccanat; Xianyao Xu; Shahab A. Akhter ABSTRACT Oxidative stress in cardiac fibroblasts (CFs) promotes transformation to myofibroblasts and collagen synthesis leading to myocardial fibrosis, a precursor to heart failure (HF). NADPH...
Journal Articles
Dis Model Mech (2015) 8 (9): 1129–1139.
Published: 1 September 2015
... of pulmonary fibrosis. In this study we addressed the role of TGFβ-ALK5 signalling during the progression of fibrosis in a two-hit mouse model of murine γ-herpesvirus 68 (MHV-68) infection on the background of pre-existing bleomycin-induced pulmonary fibrosis. Assessment of total lung collagen levels...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (2): 193–203.
Published: 1 February 2014
...Matthew Giannandrea; William C. Parks ABSTRACT Fibrosis – a debilitating condition that can occur in most organs – is characterized by excess deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of proteinases that can degrade matrix, such as matrix...