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1-4 of 4
Keywords: Cleft palate
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Journal Articles
Regina M. Friedl, Swetha Raja, Melissa A. Metzler, Niti D. Patel, Kenneth R. Brittian, Steven P. Jones, Lisa L. Sandell
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (7): dmm039073.
Published: 3 July 2019
...Regina M. Friedl; Swetha Raja; Melissa A. Metzler; Niti D. Patel; Kenneth R. Brittian; Steven P. Jones; Lisa L. Sandell ABSTRACT Cleft palate is a common birth defect, occurring in approximately 1 in 1000 live births worldwide. Known etiological mechanisms of cleft palate include defects within...
Includes: Supplementary data
Journal Articles
Kurt Reynolds, Priyanka Kumari, Lessly Sepulveda Rincon, Ran Gu, Yu Ji, Santosh Kumar, Chengji J. Zhou
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (2): dmm037051.
Published: 4 February 2019
... of gestation in humans or embryonic day 9.5 in mice. Disruptions in these early events may cause serious consequences, such as orofacial clefts, mainly cleft lip and/or cleft palate. Morphogenetic Wnt signaling, along with other signaling pathways and transcription regulation mechanisms, plays crucial roles...
Journal Articles
Kevin K. L. Lee, Emma Peskett, Charlotte M. Quinn, Rosanna Aiello, Liliya Adeeva, Dale A. Moulding, Philip Stanier, Erwin Pauws
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (11): dmm035311.
Published: 9 November 2018
... FGFR2c signalling by studying the effects of Fgfr2c overexpression. Conditional overexpression of Fgfr2c ( R26R Fgfr2c;βact ) results in craniofacial hypoplasia as well as microtia and cleft palate. Contrary to Fgfr2c null and Fgfr2c C342Y , Fgfr2c overexpression is insufficient to drive onset...
Includes: Supplementary data
Journal Articles
In collection:
Tools and Resources for Mouse Studies
Alexander Strassman, Frank Schnütgen, Qi Dai, Jennifer C. Jones, Angela C. Gomez, Lenore Pitstick, Nathan E. Holton, Russell Moskal, Erin R. Leslie, Harald von Melchner, David R. Beier, Bryan C. Bjork
Journal:
Disease Models & Mechanisms
Dis Model Mech (2017) 10 (7): 909–922.
Published: 1 July 2017
... replicating the Pierre Robin sequence-type cleft palate phenotype of other Prdm16 mutant mice. Consecutive breeding to Flpe and Emx1 IREScre deleter mice spatially restricted Prdm16 loss to regions of the forebrain expressing the homeobox gene Emx1 , demonstrating the utility of the technology...
Includes: Supplementary data
