... of retinoic acid. Drosophila nephrocyte Rabphilin Endocytic pathway Chronic kidney disease Slit diaphragm Labyrinthine channels Instituto de Salud Carlos III 10.13039/501100004587 FIS16-01402 The rabphilin 3A ( RPH3A ) gene encodes a Rab small GTPase family effector...

... outcome. In the present study, we combine rat models of chronic kidney disease (CKD) and renal Tx to dissect the effects of healthy and CKD renal grafts on healthy and CKD recipients. We show that renal function at 6 weeks post-Tx is exclusively determined by donor graft quality. Using cell tracking...

...), primarily caused by uropathogenic Escherichia coli (UPEC), is a common disease in children. Severe pyelonephritis is the primary cause of acquired renal scarring in childhood, which may eventually lead to hypertension and chronic kidney disease in a small but important fraction of patients. Preclinical...

... many decades. Recent developments in genome engineering now allow us to capitalize on the wealth of knowledge acquired over the last century. Here, we review rat models of hypertension, diabetic nephropathy, and acute and chronic kidney disease. These models have made important contributions to our...

...Diana A. Papazova; Nynke R. Oosterhuis; Hendrik Gremmels; Arianne van Koppen; Jaap A. Joles; Marianne C. Verhaar Cell-based therapy is a promising strategy for treating chronic kidney disease (CKD) and is currently the focus of preclinical studies. We performed a systematic review and meta-analysis...