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1-5 of 5
Keywords: Cholesterol
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Journal Articles
In collection:
Rare Disease Translational Research
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (12): dmm049843.
Published: 16 December 2022
...Bethany A. Freel; Benjamin A. Kelvington; Sonali Sengupta; Malini Mukherjee; Kevin R. Francis ABSTRACT Owing to the need for de novo cholesterol synthesis and cholesterol-enriched structures within the nervous system, cholesterol homeostasis is critical to neurodevelopment. Diseases caused...
Includes: Supplementary data
Journal Articles
In collection:
Neurodegenerative Disorders
Journal:
Disease Models & Mechanisms
Dis Model Mech (2021) 14 (10): dmm048929.
Published: 26 October 2021
... a novel form of intercellular communication, have been shown to influence the function/vulnerability of neurons in AD. Unlike neurons, the significance of exosomes derived from astrocytes remains unclear. In this study, we evaluated the significance of exosomes derived from U18666A-induced cholesterol...
Includes: Supplementary data
Journal Articles
In collection:
Zebrafish as a Disease Model
Rebecca A. Anderson, Kevin T. Schwalbach, Stephanie R. Mui, Elizabeth E. LeClair, Jolanta M. Topczewska, Jacek Topczewski
Journal:
Disease Models & Mechanisms
Dis Model Mech (2020) 13 (6): dmm042549.
Published: 24 June 2020
...Rebecca A. Anderson; Kevin T. Schwalbach; Stephanie R. Mui; Elizabeth E. LeClair; Jolanta M. Topczewska; Jacek Topczewski ABSTRACT Human disorders of the post-squalene cholesterol biosynthesis pathway frequently result in skeletal abnormalities, yet our understanding of the mechanisms involved...
Includes: Supplementary data
Journal Articles
Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment
In collection:
Metabolic Disorders
Journal:
Disease Models & Mechanisms
Dis Model Mech (2020) 13 (4): dmm042911.
Published: 6 April 2020
... predict statin-mediated class II protein biology. References Amundson , D. M. and Zhou , M. ( 1999 ). Fluorometric method for the enzymatic determination of cholesterol . J. Biochem. Biophys. Methods 38 , 43 - 52 . 10.1016/S0165-022X(98)00036-0 Asselah , T. , Bièche , I...
Includes: Supplementary data
Journal Articles
Anita M. Quintana, Fabrizio Picchione, Ramon I. Klein Geltink, Michael R. Taylor, Gerard C. Grosveld
Journal:
Disease Models & Mechanisms
Dis Model Mech (2014) 7 (2): 265–270.
Published: 1 February 2014
... results demonstrate that etv7 regulates the expression of the zebrafish lanosterol synthase ( lss ) gene, an essential gene in the cholesterol synthesis pathway. Furthermore, morpholino knockdown of etv7 leads to loss of hemoglobin-containing red blood cells, a phenotype that can be rescued by injection...
Includes: Supplementary data